Adjunctive High-Definition Transcranial Direct Current Stimulation in Treatment of Resistant Auditory Verbal Hallucinations in Schizophrenia: A Randomized Sham-Controlled Trial.

Background: Resistant auditory verbal hallucination (AVH) remains a disabling symptom in schizophrenia. Transcranial direct current stimulation (tDCS) and its more targeted variant, high-definition tDCS (HD-tDCS), have shown promising results in reducing AVH. We aimed to determine the effects of adjunctive HD-tDCS on various dimensions of AVH in patients with schizophrenia.

Long-Term Management of Sleep Apnea-Hypopnea Syndrome: Efficacy and Challenges of Continuous Positive Airway Pressure Therapy-A Narrative Review.

Sleep apnea-hypopnea syndrome (SAHS) is a respiratory disorder characterized by cessation of breathing during sleep, resulting in daytime somnolence and various comorbidities. SAHS encompasses obstructive sleep apnea (OSA), caused by upper airway obstruction, and central sleep apnea (CSA), resulting from lack of brainstem signaling for respiration. Continuous positive airway pressure (CPAP) therapy is the gold standard treatment for SAHS, reducing apnea and hypopnea episodes by providing continuous airflow.

Understanding asymmetric hydrogenation of alkenes catalyzed by the first-row transition metal Fe: a first-principles exploration.

First-principles analyses were performed for understanding the mechanistic details of Fe-catalysed asymmetric hydrogenation of alkenes in the presence of silane that has recently been experimentally realized. The catalytic hydrogenation is expected to proceed through initial hydride transfer from Fe-H to the CC bond of alkene, followed by σ-bond metathesis of hydrosilane to afford a chiral alkane product and an iron silyl species, which then reacts with H to regenerate the iron hydride species another σ-bond metathesis. The mechanistic details and the origin of the regioselectivity and stereoselectivity of these reactions are understood on the basis of detailed potential energy surface analysis, charge transfer and noncovalent interactions involved therein, strain energy and isodesmic studies in the solvated stage.

Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis.

Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due to the low availability of drugs across the infected nail.

Non-convergence of the blinking timescale of twelve-faceted perovskite nanocrystals observed through an advanced fluorescence correlation spectroscopy study.

Single-particle photoluminescence measurements have been extensively utilized to investigate the charge carrier dynamics in quantum dots (QDs). Among these techniques, single dot blinking studies are effective for probing relatively slower processes with timescales >10 ms, whereas fluorescence correlation spectroscopy (FCS) studies are suited for recording faster processes with timescales typically <1 ms. In this study, we utilized scanning FCS (sFCS) to bridge the ms gap, thereby enabling the tracking of carrier dynamics across an extended temporal window ranging from μs to subsecond.