Dengue is a major global health challenge, caused by the dengue virus (DENV) and transmitted through the mosquito. The four DENV serotypes (DENV1-4) infect about 400 million people annually. The non-structural protein 5 (NS5) is the most conserved DENV protein, crucial for viral replication.
View Article and Find Full Text PDFSoil can harbor enteropathogens and antimicrobial-resistant organisms in settings with domestic animals. We enrolled 49 households with young children (28 soil floors, 21 concrete floors) in Bangladesh and recorded animal ownership/management. Staff swabbed the floor of children's sleeping area with a sterile sponge and collected floor dust and a child hand rinse.
View Article and Find Full Text PDFThis study investigated the relationship between urban park size and community mental health, focusing on neighborhood crime risk as a mediator. Data were collected for 989 urban parks in Alabama, USA, from the Trust for Public Land's ParkServe database and relevant Alabama cities' Parks and Recreation Department websites. Park size was measured using Geographic Information Systems.
View Article and Find Full Text PDFBackground And Objective: Asthma is a common respiratory disease in pregnancy, with approximately 18% of cases worsening. Small airway disease (SAD) with a reported prevalence of up to 70% is now recognised as a principal indicator of poor asthma control. Impulse oscillometry (IOS) is a non-invasive, technically easier, and patient-friendly tool for detecting SAD.
View Article and Find Full Text PDFDiffuse large B-cell lymphoma (DLBCL), a subtype of non-Hodgkin's lymphoma, is the most common lymphoid malignancy in the Western world. Treatment of DLBCL has been greatly improved in recent years with the addition of the monoclonal antibody Rituximab to the gold standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone) chemotherapy regimen, but these treatments are often ineffective in patients with highly aggressive disease or patients of advanced age. While CAR-T cells have further advanced the treatment landscape of DLBCL, these often come at significant costs such as toxicity and financial costs for patients.
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