Identification and computational analysis of conserved YXXΦ motifs in the pan-serotypes of dengue virus NS5 protein and their implications in host-virus interactions.

Dengue is a major global health challenge, caused by the dengue virus (DENV) and transmitted through the mosquito. The four DENV serotypes (DENV1-4) infect about 400 million people annually. The non-structural protein 5 (NS5) is the most conserved DENV protein, crucial for viral replication.

Dirt floors and domestic animals are associated with soilborne exposure to antimicrobial resistant in rural Bangladeshi households.

Soil can harbor enteropathogens and antimicrobial-resistant organisms in settings with domestic animals. We enrolled 49 households with young children (28 soil floors, 21 concrete floors) in Bangladesh and recorded animal ownership/management. Staff swabbed the floor of children's sleeping area with a sterile sponge and collected floor dust and a child hand rinse.

Examining the indirect effect of urban park size on community mental health via neighborhood crime risk in Alabama.

This study investigated the relationship between urban park size and community mental health, focusing on neighborhood crime risk as a mediator. Data were collected for 989 urban parks in Alabama, USA, from the Trust for Public Land's ParkServe database and relevant Alabama cities' Parks and Recreation Department websites. Park size was measured using Geographic Information Systems.

Small airway disease (SAD) in asthma in pregnancy evaluated by impulse oscillometry: A cross-sectional study.

Background And Objective: Asthma is a common respiratory disease in pregnancy, with approximately 18% of cases worsening. Small airway disease (SAD) with a reported prevalence of up to 70% is now recognised as a principal indicator of poor asthma control. Impulse oscillometry (IOS) is a non-invasive, technically easier, and patient-friendly tool for detecting SAD.

Using a Natural Triterpenoid to Unlock the Antitumor Effects of Autophagy in B-Cell Lymphoma.

Diffuse large B-cell lymphoma (DLBCL), a subtype of non-Hodgkin's lymphoma, is the most common lymphoid malignancy in the Western world. Treatment of DLBCL has been greatly improved in recent years with the addition of the monoclonal antibody Rituximab to the gold standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone) chemotherapy regimen, but these treatments are often ineffective in patients with highly aggressive disease or patients of advanced age. While CAR-T cells have further advanced the treatment landscape of DLBCL, these often come at significant costs such as toxicity and financial costs for patients.