Development of a broad-spectrum epitope-based vaccine against Streptococcus pneumoniae.

Streptococcus pneumoniae (SPN) is a significant pathogen causing pneumonia and meningitis, particularly in vulnerable populations like children and the elderly. Available pneumonia vaccines have limitations since they only cover particular serotypes and have high production costs. The emergence of antibiotic-resistant SPN strains further underscores the need for a new, cost-effective, broad-spectrum vaccine.

Developing a brain inspired multilobar neural networks architecture for rapidly and accurately estimating concrete compressive strength.

Concrete compressive strength is a critical parameter in construction and structural engineering. Destructive experimental methods that offer a reliable approach to obtaining this property involve time-consuming procedures. Recent advancements in artificial neural networks (ANNs) have shown promise in simplifying this task by estimating it with high accuracy.

Risk of Hypertensive Disorders of Pregnancy in Patients With Cardiac Disease.

Background: Pregnant patients with cardiovascular disease (CVD) face increased risk of preeclampsia and preterm delivery, yet data is limited data regarding degree of risk and impact of hypertensive disorders of pregnancy (HDP) on gestational age at delivery.

Objectives: To examine HDP risk and impact on delivery timing in patients with CVD.

Methods: This retrospective cohort study included patients >18 years old who delivered between 10/1/2015 and 12/31/2020 using the Premier Healthcare Database.

A Novel Homozygous Loss-of-Function Variant in GPR156 Delineates Non-syndromic Hearing Loss.

Non-syndromic hearing loss (NSHL) is a genetically heterogeneous disorder accounting for almost 70% of the total congenital hearing loss. The implementation of rapid advanced sequencing methods has significantly contributed to the correct molecular diagnosis for several rare genetic disorders, including NHSL. Features of two probands with NHSL were clinically and genetically evaluated.

Mitochondrial control region sequences show high genetic connectivity in the brownstripe snapper, (Quoy and Gaimard, 1824) from the east coast of Peninsular Malaysia.

The Brownstripe Snapper, (Quoy and Gaimard, 1824) is a commercially important snapper extensively caught in Malaysia. We examined genetic diversity, population connectivity, and historical demographics of the , off the eastern coast of peninsular Malaysia based on an 817 bp region of the mtDNA control region sequences. Maximum likelihood gene trees demonstrated that the populations under study had limited structuring and formed a single panmictic population that lacks support for internal clades.