Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data.

West Nile virus (WNV) is a mosquito-borne zoonotic flavivirus which often causes asymptomatic infection in humans but may develop into a deadly neuroinvasive disease. In this study, we aimed to investigate variables potentially associated with human WNV infection using human and mosquito WNV surveillance and monitoring datasets, established over 20 years, from 2003 to 2022, across the province of Ontario, Canada. We combined climatic and geographic data, mosquito surveillance data (n = 3010 sites), blood donation arboviral detection testing data in the human population, and demographic and socio-economic data from Canadian population censuses.

Meis transcription factors regulate cardiac conduction system development and adult function.

Aims: The Cardiac Conduction System (CCS) is progressively specified during development by interactions among a discrete number of Transcriptions Factors that ensure its proper patterning and the emergence of its functional properties. Meis genes encode homeodomain transcription factors (TFs) with multiple roles in mammalian development. In humans, Meis genes associate with congenital cardiac malformations and alterations of cardiac electrical activity, however the basis for these alterations has not been established.

A single-photon emitter coupled to a phononic-crystal resonator in the resolved-sideband regime.

A promising route towards the deterministic creation and annihilation of single-phonons is to couple a single-photon emitter to a mechanical resonator. The challenge lies in reaching the resolved-sideband regime with a large coupling rate and a high mechanical quality factor. We achieve this by coupling self-assembled InAs quantum dots to a small mode-volume phononic-crystal resonator with mechanical frequency Ω/2π = 1.

Modelling freckles and spurious grain formation in directionally solidified superalloy castings.

Segregation channels with misoriented spurious grains, known as freckles, are an unacceptable casting defect in superalloy turbine blades. A digital-twin method to predict segregation channels was proposed in our previous studies; however, the formation of spurious grains was ignored. Here, we extend the digital twin methodology by incorporating dendrite fragmentation, which is recognized as the predominant mechanism in the formation of spurious grains.