Methylation of and Are Risk Factors and Potential Biomarkers for Cervical Lesions.

Background: The correlation between methylation of paired box gene 1 () and sex determining region Y-box 1 () with human papillomavirus (HPV) infection and the progression of cervical lesions is not well understood. This study aims to explore the potential value of and as diagnostic biomarkers for cervical diseases.

Methods: A total of 139 cervical biopsy tissue samples were obtained from the Department of Pathology, the Seventh Medical Center, Chinese PLA General Hospital from 2021 to 2023.

Investigating Risk Factors for Racial Disparity in E-Cigarette Use with PATH Study.

Background: Previous research has identified differences in e-cigarette use and socioeconomic factors between different racial groups However, there is little research examining specific risk factors contributing to the racial differences.

Objective: This study sought to identify racial disparities in e-cigarette use and to determine risk factors that help explain these differences.

Methods: We used Wave 5 (2018-2019) of the Adult Population Assessment of Tobacco and Health (PATH) Study.

Vertical Gradient of Nitryl Chloride and Implications for Atmospheric Photochemistry in Pearl River Delta, China, during Wintertime.

Nitryl chloride (ClNO) is a key precursor of chlorine radicals, influencing atmospheric oxidation and secondary pollutants formation. Few studies have examined the ClNO chemistry from the perspective of the planetary boundary layer. Here, we conducted a vertically resolved investigation of ClNO at six heights (ranging from 5 to 335 m) on a 356 m tower in the Pearl River Delta, China, during winter 2021.

Feasibility analysis of non-electrocardiogram-triggered chest low-dose computed tomography using a kV-independent reconstruction algorithm for predicting cardiovascular disease risk in patients receiving maintenance hemodialysis.

Objectives: This study aimed to evaluate the feasibility and accuracy of non-electrocardiogram (ECG)-triggered chest low-dose computed tomography (LDCT) with a kV-independent reconstruction algorithm in assessing coronary artery calcification (CAC) degree and cardiovascular disease risk in patients receiving maintenance hemodialysis (MHD).

Methods: In total, 181 patients receiving MHD who needed chest CT and coronary artery calcium score (CACS) scannings sequentially underwent non-ECG-triggered, automated tube voltage selection, high-pitch chest LDCT with a kV-independent reconstruction algorithm and ECG-triggered standard CACS scannings. Then, the image quality, radiation doses, Agatston scores (ASs), and cardiac risk classifications of the two scans were compared.

The association of gut microbiota, immunocyte dynamics, and protein-protein ratios with tuberculosis susceptibility: a Mendelian randomization analysis.

This study focused on the relationships among gut microbiota, plasma protein ratios, and tuberculosis. Given the unclear causal relationship between gut microbiota and tuberculosis and the scarcity of research on relevant plasma protein ratios in tuberculosis, Mendelian randomization analysis (MR) was employed for in-depth exploration. By analyzing the GWAS data of individuals with European ancestry (the FinnGen dataset included 409,568 controls and 2613 cases), using the two-sample MR method, we focused on evaluating the impact of immunocyte-mediated gut microbiota on tuberculosis and the associations between 2821 plasma protein-to-protein ratios and tuberculosis.