Personality matters: Exploring the associations of personality traits with mood and somatic symptoms in multiple sclerosis.

Background: Research suggest that personality traits influence the mood and somatic symptoms in various different clinical populations. Neuroticism, extraversion, conscientiousness, openness to experience, and agreeableness have been identified as potential predictors of mood and somatic symptoms. However, the literature on personality traits and symptom outcomes in multiple sclerosis (MS) is limited, highlighting the necessity for more in-depth research.

Beyond Caregiving: Daily Pleasant Activities among Caregivers to Older Adults with and without Dementia.

Objectives: Limited research has explored caregivers' activities beyond caregiving duties, which may offer positive experiences and counterbalance caregiving stress. This study aimed to (a) identify the most pleasant non-caregiving activities, (b) assess time allocation based on activity categories and pleasantness, and (c) investigate the association between activity pleasantness and duration, considering differences between caregivers to older adults with Alzheimer's Disease and Related Dementias (ADRD) and those without.

Methods: This study included 2,136 caregivers (33% ADRD) from the 2017 National Study of Caregiving (NSOC) who participated in a time diary interview.

Flow-Adjusted Trabeculectomy.

As one of the most efficacious glaucoma surgical techniques, trabeculectomy is considered by many surgeons to be the "gold standard" intra-ocular pressure (IOP)-reducing intervention. The purpose of this study is to present our intra-operative flow-adjusted surgical method, which aims to provide safety and efficacy more simply than previous methods. Retrospectively, we evaluated outcomes for trabeculectomy or phacotrabeculectomy in surgery-naïve eyes over three years for patients with glaucoma not associated with other ocular co-morbidities.

Dos and don'ts for conducting mediation analysis: A commentary with practical tips to avoid common problems.

Mediation analyses allow for exploration of causal mechanisms that explain how a predictor is related to an outcome. Tests of mediation are fundamental to addressing some of the most consequential questions in rehabilitation science. In recent decades, the development of easy-to-use analytical tools has made conducting statistical tests of mediation more accessible to researchers.

Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial.

Background: Fatigue is one of the most disabling symptoms reported by people with multiple sclerosis. Although behavioural and pharmacological interventions might be partly beneficial, their combined effects have not been evaluated for multiple sclerosis fatigue, or examined with sufficient consideration of characteristics that might affect treatment response. In this comparative effectiveness research trial, we compared the effectiveness of cognitive behavioural therapy (CBT), modafinil, and their combination for treating multiple sclerosis fatigue.