Publications by authors named "A K Kesarwani"

Article Synopsis
  • - The discovery of biomarkers for drug development is constrained by limited tissue samples from core needle biopsies, which can hinder the analysis of tissue heterogeneity and cell interactions due to standard 'omics platforms consuming large amounts of tissue.
  • - Current spatial transcriptomics technologies have low throughput and limited transcriptome coverage, while the Digital Spatial Profiling (DSP) method allows for scalable analysis of the entire transcriptome and high-plex protein analysis from a single tissue slide.
  • - The DSP Scientific Consortium has established best practices to enhance the use of spatial biology tools in drug discovery, aiming to optimize tissue analysis across various research fields to better understand disease biology and discover potential therapeutic targets.
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Natural phytochemicals are well known to protect against numerous metabolic disorders. Anthocyanins are vacuolar pigments belonging to the parent class of flavonoids. They are well known for their potent antioxidant and gut microbiome-modulating properties, primarily responsible for minimizing the risk of cardiovascular diseases, diabetes, obesity, neurodegenerative diseases, cancer, and several other diseases associated with metabolic syndromes.

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Background: Retinitis pigmentosa (RP) is a hereditary retinal disease which leads to visual impairment. The onset and progression of RP has physiological consequences that affects the ocular environment. Some of the key non-genetic factors which hasten the retinal degeneration in RP include oxidative stress, hypoxia and ocular inflammation.

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This study aims to understand the regulatory mechanism of the β-carotene homeostasis by establishing transgene-free genome editing in banana. Carotenoid cleavage dioxygenases (CCDs) belong to a miniature gene family having an imperative role in the intricated carotenoid metabolism in plants. Here, the expression pattern of multiple CCDs was correlated with the levels of carotenoid accumulation in two contrasting cultivars, viz.

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Introduction: Pressure injury (PI) is a potentially serious condition that is often a consequence of other medical illnesses. It remains a challenge for the clinicians and the researcher to fully understand and develop a technique for comprehending pathogenicity, prevention and treatment. Several animal models have been created to understand the multifaceted cellular and biochemical processes of PI.

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