Temporal variability of microplastics in shrimp (Litopenaeus vannamei), feed, water and sediments of coastal and inland culture ponds.

Aquaculture, particularly shrimp farming, is crucial for global food security. However, the increasing presence of microplastics (MPs) in marine environments, shrimp feeds, and atmospheric particles has made MP contamination in shrimp tissues inevitable. This study systematically investigates the abundance, characteristics, and temporal trends (from 15th to the 120th day of culture) of MPs contamination in Litopenaeus vannamei, along with associated feed, water, and sediment across 12 shrimp ponds of two major shrimp-producing regions of India.

A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer.

The major driver oncogenes MYC, mutant KRAS, and mutant TP53 often coexist and cooperate to promote human neoplasia, which results in anticancer therapeutic opportunities within their downstream molecular programs. However, little research has been conducted on whether redundancy and competition among oncogenes affect their programs and ability to drive neoplasia. By CRISPR‒Cas9-mediated downregulation we evaluated the downstream proteomics and transcriptomics programs of MYC, mutant KRAS, and mutant TP53 in a panel of cell lines with either one or three of these oncogenes activated, in cancers of the lung, colon and pancreas.

Diet characteristics of tidal creek-associated fishes of the northeastern Arabian Sea with special reference to microplastic ingestion.

The present study assessed the diet characteristics, trophic guild structure, and microplastics (MPs) ingestion by a group of fish sourced from the tidal creeks of the Mumbai coast along the Eastern Arabian Sea. The diet patterns were characterized using gastro-somatic index (GaSI), relative length of gut (RGL), diet overlap (α), diet breadth (B), and relative abundance of food items (%IOP), with a special emphasis on MPs contamination. The findings revealed that teleost and shrimps are the most preferred food items for these species.