Upstream-binding protein-1 promotes breast tumorigenesis by inducing NRG2-mediated metastasis, plasticity, and macrophage polarization.

Upstream binding protein 1 (UBP1) is a transcription factor (TF) of the CP2/grainyhead family involved in various biological processes, including cancer cell proliferation, differentiation, and embryonic development. While other mammalian grainyhead-like TFs have been linked to different cancers, including breast cancer (BC), the role of UBP1 in BC remains unexplored. In this study, we provide a preliminary investigation into the novel functions of UBP1 in BC.

Extremely Unusual Coronary Involvement in Cardiac Sarcoidosis.

Left ventricular (LV) regional wall motion abnormalities are common in cardiac sarcoidosis but coronary occlusion is very rare. Here, we report a case of cardiac sarcoidosis with very unusual coronary involvement. A 43-year-old man presented with a persistent cough and a history of uveitis 6 months back with no other comorbidities.

Microalgal biorefineries in sustainable biofuel production and other high-value products.

Microalgae has been emerging as a promising solution against the backdrop of the global need for sustainable, eco-friendly alternatives. This review article analyses the use of photosynthetic microalgae as an important resource for sustainable biofuel and high value bioproduct production, emphasizing the potential of self-sustaining microalgae biorefineries. A closed-loop, integrated multi-product producing microalgal biorefinery approach could significantly reduce the indicated negative environmental and energy impact from standalone microalgal biofuel generation.

Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases.

Brain metastases frequently develop in patients with non-small cell lung cancer (NSCLC) and are a common cause of cancer-related deaths, yet our understanding of the underlying human biology is limited. Here we performed multimodal single-nucleus RNA and T cell receptor, single-cell spatial and whole-genome sequencing of brain metastases and primary tumors of patients with treatment-naive NSCLC. Chromosomal instability (CIN) is a distinguishing genomic feature of brain metastases compared with primary tumors, which we validated through integrated analysis of molecular profiling and clinical data in 4,869 independent patients, and a new cohort of 12,275 patients with NSCLC.

The Critical Role of Penicillin in Syphilis Treatment and Emerging Resistance Challenges.

Syphilis, a global healthcare burden, is a sexually transmitted infection caused by the spirochete , a spiral-shaped, Gram-negative obligate human pathogen. Despite its easy identification and treatability, the disease affects over 50 million people worldwide, with 8 million new cases in the 15-49 age group annually, as per the WHO 2024 report. If left untreated, syphilis progresses through its primary, secondary, latent, and tertiary stages, causing severe complications like neurosyphilis, congenital syphilis, and organ damage.