Publications by authors named "A K Houghton"
Reproducibility of neuroimaging research on infant brain development remains limited due to highly variable protocols and processing approaches. Progress towards reproducible pipelines is limited by a lack of benchmarks such as gold standard brain segmentations. Addressing this core limitation, we constructed the Baby Open Brains (BOBs) Repository, an open source resource comprising manually curated and expert-reviewed infant brain segmentations.
View Article and Find Full Text PDFPremalignant Progression in the Lung: Knowledge Gaps and Novel Opportunities for Interception of Non-Small Cell Lung Cancer. An Official American Thoracic Society Research Statement.
Am J Respir Crit Care Med
September 2024
Article Synopsis
- Lung cancer remains the leading cause of cancer deaths globally, highlighting the need for better understanding of its early development stages to enable timely interventions.
- An international team of scientists identified knowledge gaps in how premalignant lung lesions progress to lung cancer and developed research questions to fill these gaps and guide future investigations.
- Addressing these gaps is crucial for improving screening and early detection methods, which could lead to innovative strategies that effectively reduce lung cancer incidence and enhance patient outcomes.
Article Synopsis
- * Research shows that blocking CXCR2 can slow tumor growth, but neutrophils are still recruited to tumors; instead, the inhibitors modify how neutrophils work, preventing them from turning into immune suppressive cells that inhibit lymphocyte activity.
- * Clinical trials are ongoing to test the effectiveness of CXCR1/2 inhibitors in combination with ICIs, and findings indicate these treatments do not lead to increased infection risks despite impacting neutrophil function.
Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study.
Dev Cogn Neurosci
August 2024
Background: There is an imminent need to identify neural markers during preadolescence that are linked to developing depression during adolescence, especially among youth at elevated familial risk. However, longitudinal studies remain scarce and exhibit mixed findings. Here we aimed to elucidate functional connectivity (FC) patterns among preadolescents that interact with familial depression risk to predict depression two years later.
View Article and Find Full Text PDFHuman cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices to transmodal association cortices. Here, we investigate the hypothesis that the development of functional connectivity during childhood through adolescence conforms to the cortical hierarchy defined by the sensorimotor-association axis. We tested this pre-registered hypothesis in four large-scale, independent datasets (total n = 3355; ages 5-23 years): the Philadelphia Neurodevelopmental Cohort (n = 1207), Nathan Kline Institute-Rockland Sample (n = 397), Human Connectome Project: Development (n = 625), and Healthy Brain Network (n = 1126).
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