Publications by authors named "A K Hedman"
Background: The World Health Organization classified coronavirus disease (COVID-19) as a pandemic by March 11, 2020. Children had a milder disease than adults, and many were asymptomatic. The pandemic could be seen as a natural experiment with several changes, including time spent at home.
View Article and Find Full Text PDFBackground: Underlying immunological mechanisms in children with moderate-to-severe asthma are complex and unclear. We aimed to investigate the association between blood inflammatory parameters and asthma burden in children with moderate-to-severe asthma.
Methods: Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6-17 years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries.
Background: Impaired pulmonary function carries significant risks for lung, cardiovascular, and metabolic disorders.
Research Question: Can circulating protein biomarkers of pulmonary function provide insight into the pathophysiologic features of lung function impairment and links to comorbidities?.
Study Design And Methods: We analyzed plasma levels of 2,922 proteins in 32,493 UK Biobank participants (53% female; mean [SD] age, 57 [8] years) to investigate their associations with spirometry measures of lung function (FEV, FVC, FEV to FVC ratio), and with obstructive (n = 4,713) and restrictive (n = 3,886) spirometry patterns.
Objective: Interstitial lung disease (ILD) is an important cause of mortality in patients with rheumatoid arthritis (RA). Early RA-ILD detection is essential to improve prognosis. Here, we investigated eight serological biomarkers that may contribute to RA-ILD detection.
View Article and Find Full Text PDFArticle Synopsis
- Monozygotic (MZ) twins, typically considered genetically identical, actually can have differing DNA variants due to early post-zygotic events, which may relate to differences in disease manifestation.
- In a study involving whole genome sequencing of 17 pairs of MZ twins discordant for psychotic disorders, researchers found rare genetic variants unique to affected individuals, including specific genes linked to schizophrenia and bipolar disorder.
- The research identified significant genetic variations, such as deleterious missense variants and rare genic copy number variants (CNVs), suggesting a potential link to the disorders, and emphasizes the need for further investigation in this area.