Publications by authors named "A K E Bonamy"
Importance: An association between maternal preeclampsia and an increased risk of cardiovascular disease in the offspring is plausible, but evidence in this area is limited.
Objective: To investigate (1) the association between maternal preeclampsia and risks of ischemic heart disease (IHD) and stroke in the offspring, (2) whether the association varies by severity or timing of onset of preeclampsia, and (3) the role of preterm birth and small for gestational age (SGA) birth, both of which are related to preeclampsia and cardiovascular diseases, in this association.
Design, Setting, And Participants: This multinational population-based cohort study obtained data from Danish, Finnish, and Swedish national registries.
Article Synopsis
- - The study investigated how well a machine learning model for triaging medical reports agrees with decisions made by human primary care physicians, focusing on symptom reports submitted via smartphones.
- - A naïve Bayes model was developed to classify reports based on urgency, tested against 300 reports and compared to a majority vote of a panel of five doctors, revealing low reliability in their assessments.
- - Results showed that both interrater and intrarater agreement among physicians was low, indicating a challenge in using human judgments as a reliable reference for automating triage decisions with machine learning.
Aim: This study investigated patent ductus arteriosus (PDA) treatment and neurodevelopmental outcomes when extremely preterm born children reached 6.5 years.
Method: Our cohort was 435 children with neonatal PDA treatment data and neurodevelopmental follow-up data, born in 2004-2007, who participated in the Extremely Preterm Infants in Sweden Study.
Article Synopsis
- Maternal overweight and obesity have been linked to higher risks of cardiovascular and metabolic diseases in their children, prompting a study to examine these associations using data from over 2.2 million live births in Sweden from 1992 to 2016.
- The research found that cardiovascular disease rates increased significantly with maternal obesity severity; children of severely obese mothers were 2.5 times more likely to develop cardiovascular diseases compared to children of normal-weight mothers.
- The study suggested that these risks may be partly due to complications during birth, such as asphyxia, and confirmed these trends through sibling comparisons, indicating a consistent relationship between maternal BMI and child health outcomes.
In this prospective cohort study of healthy full-term infants, we hypothesized that high-sensitivity cardiac troponin T (hs-cTnT) would be elevated in cord blood, compared with adult reference values, and that it would further increase over the first days of age. Cardiac troponin T has been shown to be significantly increased in healthy full-term newborns compared with adult reference values, but there is no established reference range. Most studies of cTnT in newborns have been performed before the introduction of high-sensitivity cTnT (hs-cTnT) assay.
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