Publications by authors named "A K Dobriyal"
Article Synopsis
- The study investigates the effectiveness and safety of endoscopic transsphenoidal surgery (ETSS) for treating adrenocorticotropic hormone (ACTH)--secreting pituitary adenomas that cause Cushing's disease (CD), analyzing data from surgeries performed between January 2015 and February 2022.
- Out of 41 patients who underwent ETSS, the initial remission rate was 85.4% using standard criteria, and after including results from a small number of repeat surgeries, the overall remission rate rose to 90.2%.
- Postoperative complications were relatively low, with only a small percentage experiencing diabetes insipidus and no serious complications like meningitis or vascular injury being reported.
The present work is based on analysis of inhibitory activity of alpha-amylase inhibitor in selected cultivars of Phaseolus vulgaris of Uttarakhand. Fifteen samples were assessed for inhibitory activity of alpha-amylase inhibitor. Significant variations were found in different cultivars.
View Article and Find Full Text PDFAdvancement in nanotechnology has improved ways for large-scale production and characterization of nanoparticles of physiologically important metals. The current study explores the impact of Zinc Oxide Nanoparticles (ZnO-NP) and Chitosan-Zinc oxide nano-bioformulation (CH-ZnO) in tissue culture raised callus of . Results indicated augmented biomass in CH-ZnO treated callus, while a reduced biomass was observed in ZnO-NP treated callus, at all the concentrations tested.
View Article and Find Full Text PDFObjective: The therapeutic effects of low molecular weight heparins (LMWH) may extend past thrombosis prevention, with preclinical evidence demonstrating anti-metastatic properties. Clinical evidence on the topic, however, remains controversial. A systematic review of preclinical evidence may help elucidate reasons for this contradictory evidence.
View Article and Find Full Text PDFPurpose: Unplanned emergency department (ED) visits and hospitalizations are common during systemic cancer therapy. To determine how patients with cancer trade off treatment benefit with risk of experiencing an ED visit or hospitalization when deciding about systemic therapy, we undertook a discrete choice experiment.
Materials And Methods: Patients with breast, colorectal, or head and neck cancer contemplating, receiving, or having previously received systemic therapy were presented with 10 choice tasks (5 in the curative and 5 in the palliative setting) that varied on 3 attributes: benefit, risk of ED visit, and risk of hospitalization.