Publications by authors named "A K Dhakal"
Paediatric dialysis services have been available in Nepal for three decades but are limited to a few tertiary referral centres in major cities. The availability of a small number of paediatric nephrologists, an increasing number of adult nephrologists, and a modest increase in dialysis facilities have contributed to the gradual expansion of paediatric nephrology and kidney replacement therapy services in Nepal over the last decade. These services have grown steadily and will continue to grow because of the positive impact of government support for kidney replacement therapy and various public health initiatives to promote kidney health.
View Article and Find Full Text PDFCryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling the determination of high-resolution 3-Dimensional (3D) structures of large biological macromolecules. Protein particle picking, the process of identifying individual protein particles in cryo-EM micrographs for building protein structures, has progressed from manual and template-based methods to sophisticated artificial intelligence (AI)-driven approaches in recent years. This review critically examines the evolution and current state of cryo-EM particle picking methods, with an emphasis on the impact of AI.
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- Researchers sequenced 470 genomes of domesticated river and swamp buffaloes and their wild ancestors to investigate the genetic factors influencing domestication and productivity in Asian water buffaloes.* -
- Wild swamp buffaloes maintain ancestral morphology, while river buffaloes show distinct traits, yet both have genomes that align closely with wild counterparts; genetic diversity varies significantly across regions.* -
- Key findings indicate that artificial selection has led to significant genetic adaptations in traits like reproduction, milk production, and coat color, highlighting how domestication affects evolutionary changes in these animals.*
Article Synopsis
- * A qualitative study involving 35 patients with non-communicable diseases revealed that facilitators for using healthcare services included free medicines, accessibility, and positive interactions with providers, while barriers included insufficient services, high costs, and lack of information.
- * The study concludes that improving the utilization of NCD services can be achieved by enhancing patient knowledge, motivation, and addressing misconceptions, along with strengthening healthcare accessibility and provider-patient communication.
We report the efficacy of trastuzumab deruxtecan (T-DXd) in treating human epidermal growth factor receptor 2 (HER2) low, type ID leptomeningeal breast cancer (LMD) (with positive cerebrospinal fluid [CSF] cytology and hydrocephalus as the only abnormal imaging finding) and the diagnostic and monitoring utilization of a novel microfluidic platform called CNSide™. Breast cancer LMD is associated with poor prognosis, and effective treatments are lacking. Our case highlights two crucial aspects related to the treatment and monitoring of breast cancer LMD.
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