Green Synthesis and Biological Aspect of Seven-Membered Azepine Hybrids: A Recent Update".

Seven-membered nitrogen-containing heterocycles, particularly azepine-based compounds, represent an intriguing class of molecules with vast arrays of applications. These compounds have garnered considerable attention in synthetic and medicinal chemistry due to their non-planar, non-aromatic features, which offer structural flexibility and diversity to design new drugs with improved pharmacological properties. This review summarizes the recent advances in the synthesis of azepine derivatives, including eco-friendly methodologies that align with the principles of green chemistry, which emphasize atom economy, sustainability, and waste reduction.

Role of Shirodhara and Abhyanga on serum cortisol in Anxiety - A case report.

Chittodvega, classified as a Mano-Vikara (psychological disorder) in Ayurveda, can be correlated with general anxiety disorder. The disturbance of Vata Dosha plays a critical role in its manifestation. Ayurvedic treatments such as Abhyanga (oleation) and Shirodhara (dripping of medicated oil or other suitable liquid on forehead) are known to pacify Vata.

Genome wide landscaping of copy number variations for horse inter-breed variability.

Copy number variations (CNVs) have become widely acknowledged as a significant source of genomic variability and phenotypic variance. To understand the genetic variants in horses, CNVs from six Indian horse breeds, Manipuri, Zanskari, Bhutia, Spiti, Kathiawari and Marwari were discovered using Axiom Equine Genotyping Array. These breeds differed in agro-climatic adaptation with distinct phenotypic characters.

Barriers to Yearly Diabetic Retinopathy Screening Attendance: A Retrospective Clinical Audit.

Diabetic retinopathy is the most common sight-threatening complication of diabetes, necessitating regular monitoring of progression via diabetic eye screening (DES). The National Institute for Health and Care Excellence (NICE) recommends DES annually for diabetic patients aged 12 years and older. This retrospective clinical audit assessed the reasons behind non-attendance and evaluated the adherence to guidelines set by NICE in a general practice with approximately 9000 patients.

Emergency medical services level of training is associated with mortality in trauma patients: A combined prehospital and in hospital database analysis.

Background: There is conflicting evidence regarding emergency medical service (EMS) provider level of training and outcomes in trauma. We hypothesized that advanced life support (ALS) provider transport is associated with lower mortality compared with basic life support transport.

Methods: We performed secondary analysis of a combined prehospital and in-hospital database of trauma patients utilizing ESO electronic medical records from 2018 to 2022.