Threading the Eye of the Needle: Designing the Next Generation of Crop Protection Solutions in an Increasingly Deglobalized Regulatory Landscape.

The growing global needs for food and feed and the impact of climate change on agriculture demand innovative and sustainable solutions to protect against crop losses and to improve yields worldwide. To facilitate the timely discovery and development of new sustainable crop protection products with favorable human health and environmental safety profiles, the development of new approach methodologies (NAMs) is essential to predict potential risk and to perform safety assessment early in the discovery process. Significant advances in NAM research have been made in recent years.

Proximal patellar tendon injury with avulsed periosteal sleeve: A case report and long-term follow-up.

Introduction: Acute patellar tendon injuries in children are rare but increasing due to more high-energy sports participation. These injuries often involve bony fractures, with isolated tendon avulsions being uncommon. Timely diagnosis and surgical intervention are essential to restore knee function and pre-injury activity levels.

Muscle power is associated with higher levels of walking capacity and self-reported gait performance and physical activity in individuals with cerebral palsy.

Introduction: The purpose of this study was to investigate the relationships between a Power Leg Press test (PLP) with walking capacity and self-reported performance and participation in individuals with Cerebral Palsy (CP), and to compare the strength of the associations between two power tests (PLP and isokinetic (IsoK)) with walking capacity.

Methods: Ambulatory individuals with CP (n = 33; age 17.89 ± 7.

Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID.

Persistent symptoms after COVID-19 constitute the long COVID syndrome, also called post-acute sequelae of SARS-CoV-2 infection (PASC). COVID-19 vaccines reduce the gravity of ensuing SARS-CoV-2 infections. However, whether vaccines also have an impact on PASC remain unknown.

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice.

Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the apolipoprotein E gene (mdx-ApoE) we previously reported severe myofiber damage exacerbation via histology with large fibro-fatty infiltrates and phenotype humanization with ambulation dysfunction when fed a cholesterol- and triglyceride-rich Western diet (mdx-ApoE). Herein, we performed comparative lipidomic and metabolomic analyses of muscle, liver and serum samples from mdx and mdx-ApoE mice using solution and high-resolution-magic angle spinning (HR-MAS) H-NMR spectroscopy.