A systematic literature review of driver behaviour in blind spot: Assessing risk and influencing factors for enhanced ergonomics in vehicle design.

Risk associated with vehicle blind spot is a critical concern for road traffic safety that poses a serious threat to drivers as well as vulnerable road users. While driving on the road, it is necessary for drivers to check their mirrors before attempting lane changing, overtaking, turning, or any kind of manoeuvring pattern. But still, there remains some areas around the vehicle that are not visible to driver's peripheral vision even through checking mirrors, known as vehicle blind spots.

Developing theoretically underpinned primary care resources for patients with asthma: an exemplar from the IMPART trial.

Aim: This article reports on the development of patient resources for the IMPlementing IMProved Asthma self-management as RouTine (IMPART) programme that aimed to encourage patients to attend asthma reviews (invitation letters), encourage patients to enquire about asthma action plans (posters), and equip patients with the knowledge to manage their asthma (information website).

Background: To improve supported asthma self-management in UK primary care, the IMPART programme developed a whole-systems approach (patient resources, professional education, and organisational strategies).

Methods: Linked to behaviour change theory, we developed a range of patient resources for primary care general practices (an information website, invitation letters to invite patients for asthma reviews, and posters to encourage asthma action plan ownership).

Understanding the processes underpinning IMPlementing IMProved Asthma self-management as RouTine (IMPART) in primary care: study protocol for a process evaluation within a cluster randomised controlled implementation trial.

Background: Providing supported self-management for people with asthma can reduce the burden on patients, health services and wider society. Implementation, however, remains poor in routine clinical practice. IMPlementing IMProved Asthma self-management as RouTine (IMPART) is a UK-wide cluster randomised implementation trial that aims to test the impact of a whole-systems implementation strategy, embedding supported asthma self-management in primary care compared with usual care.

Spontaneous Peptide Ligation Mediated by Cysteamine.

The fundamental and universal nature of life's exploitation of peptides suggests they must have played a vital role during the onset of life, but their spontaneous chemoselective synthesis in water remains unknown. Aminonitriles () are widely accepted as prebiotic precursors of both amino acids and peptides, but they do not spontaneously polymerize in water to yield peptides. Here, we demonstrate that the simple prebiotically plausible aminothiol, cysteamine (), participates in Strecker chemistry to furnish β-mercaptoethyl-α-aminonitriles () and β-mercaptoethyl-amino acids (), which are predisposed to spontaneously form peptides in water.

Analysis of cell free DNA to predict outcome to bevacizumab therapy in colorectal cancer patients.

To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome footprints (NF) and methylation profiles in metastatic colorectal cancer (mCRC) patients. Low-coverage whole-genome sequencing (LC-WGS) was performed on matched tumor and plasma samples, collected from 74 mCRC patients from the AC-ANGIOPREDICT Phase II trial (NCT01822444), and analysed for CIN and NFs. A validation cohort of plasma samples from the University Medical Center Mannheim (UMM) was similarly profiled.