Substituent-driven ESIPT in Chromeno-pyrroloquinoline probe for differentiating normal and cancer cells.

Despite significant advancements in the structural flexibility and functional diversity of fluorescent molecular sensors, the chromophores often require complex synthetic processes and are typically designed to perform only a specific function. Herein, we have demonstrated the unique features of fluorophores based on a fused coumarin-indole scaffold, which are synthetically available via a one-step reaction. Four fluorophores (ICH, ICEst, ICOMe, and ICNMe2) with varying substituents were synthesized and characterized.

Elf autoencoder for unsupervised exploration of flat-band materials using electronic band structure fingerprints.

Two-dimensional materials with flat electronic bands are promising for realising exotic quantum phenomena such as unconventional superconductivity and nontrivial topology. However, exploring their vast chemical space is a significant challenge. Here we introduce elf, an unsupervised convolutional autoencoder that encodes electronic band structure images into fingerprint vectors, enabling the autonomous clustering of materials by electronic properties beyond traditional chemical paradigms.

Multilayered screening for multi-targeted anti-Alzheimer's and anti-Parkinson's agents through structure-based pharmacophore modelling, MCDM, docking, molecular dynamics and DFT: a case study of HDAC4 inhibitors.

Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are neurological conditions that primarily impact the elderly having distinctive traits and some similarities in terms of symptoms and progression. The multifactorial nature of AD and PD encourages exploring potentiality of multi-target therapy for addressing these conditions to conventional, the "one drug one target" strategy. This study highlights the searching of potential HDAC4 inhibitors through multiple screening approaches.

Modulating the Selective Enrichment and Depletion of Ions Using Electrorheological Fluids in Variable-Area Microchannels.

Electrorheological fluids are suspensions that are characterized by a strong functional dependence of their constitutive behavior on the local electric field. While such fluids are known to be promising in different applications of microfluidics including electrokinetic flows, their capabilities of controlling ion transport and preferential solute segregation in confined fluidic systems remain to be explored. In this work, we bring out the unique role of electrorheological fluids in orchestrating the selective enrichment and depletion of charged species in variable area microfluidic channels.

Preliminary observations in cortical excitability changes using transcranial magnetic stimulation (TMS), it's correlation with diffusion tensor imaging (DTI) in subjects with neuromyelitis optica spectrum disorder (NMOSD).

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing central nervous system disease most commonly associated with aquaporin-4 antibodies (AQP4-Ab) and Myelin oligodendrocyte glycoprotein (MOG) antibodies. These demyelinating disorders influence cortical excitability, which has been studied using advanced imaging techniques and transcranial magnetic stimulation (TMS) in our study.

Methods: This is a prospective study of 30 subjects.