Publications by authors named "A K Adeyemo"
The Research Program () seeks to accelerate biomedical research and address the underrepresentation of minorities by recruiting over one million ethnically diverse participants across the United States. A key question is how self-identification with discrete, predefined race and ethnicity categories compares to genetic diversity at continental and subcontinental levels. To contextualize the genetic diversity in , we analyzed ~2 million common variants from 230,016 unrelated whole genomes using classical population genetics methods, alongside reference panels such as the 1000 Genomes Project, Human Genome Diversity Project, and Simons Genome Diversity Project.
View Article and Find Full Text PDFSingle cell studies have transformed our understanding of cellular heterogeneity in disease but the need for fresh starting material can be an obstacle, especially in the context of international multicenter studies and archived tissue. We developed a protocol to obtain high-quality cells and nuclei from dissected human skeletal muscle archived in the preservative Allprotect® Tissue Reagent. After fluorescent imaging microscopy confirmed intact nuclei, we performed four protocol variations that compared sequencing metrics between cells and nuclei enriched by either filtering or flow cytometry sorting.
View Article and Find Full Text PDFBackground: Haemonchosis is a major parasitic infestation in ruminant livestock, causing significant economic losses annually. The causative organisms are helminths of the genus spp. Detection of the causative agent is important for effective management and control of the disease.
View Article and Find Full Text PDFArticle Synopsis
- The study developed a prediction model for aminoglycoside-induced ototoxicity (hearing loss) in a cohort of 153 adults undergoing anti-TB treatment with Streptomycin.
- Key factors influencing the risk of ototoxicity included age, cumulative dosage of Streptomycin, and baseline hearing levels, with age and dosage significantly increasing the risk.
- The model demonstrated good predictive ability, with training and validation areas under the curve indicating strong discrimination for identifying those at risk for hearing loss.
Background: Apolipoprotein L1 gene () variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of variants with CKD in West Africans, a major group in the Black population.
Methods: We conducted a case-control study involving participants from Ghana and Nigeria who had CKD stages 2 through 5, biopsy-proven glomerular disease, or no kidney disease.