Publications by authors named "A Jura-Poltorak"
Article Synopsis
- - The study highlights the urgent need for non-invasive biomarkers for the early diagnosis of inflammatory bowel disease (IBD), focusing on the serum levels of occludin, claudin-2, and zonulin in patients undergoing treatment.
- - Key findings indicate that levels of occludin decreased and claudin-2 increased in IBD patients compared to healthy individuals; zonulin levels also rose in Crohn’s disease patients, showing promising diagnostic capabilities.
- - Treatment with the TNF-α inhibitor adalimumab improved biomarker levels in ulcerative colitis patients, suggesting potential for these markers as effective tools in diagnosing and monitoring IBD.
Rheumatoid arthritis (RA) is associated with significant systemic and local bone loss. The aim of this study was to assess whether or not 15-month tumor necrosis factor α inhibitor (TNFαI) therapy in combination with methotrexate (MTX) affects circulating levels of sclerostin (SOST) in female RA patients. Plasma levels of SOST were measured using immunoassays kits.
View Article and Find Full Text PDFThe aim of our case-control study was to identify novel biomarkers of Crohn's disease (CD) that hold the potential to be employed in both disease diagnosis and monitoring activity. In the context of the contribution of intestinal barrier integrity and immune response to the pathogenesis of CD, we assessed the serum concentrations of proguanylin (pro-GN), pentraxin 3 (PTX3) and S100A12 in 20 patients before and after anti-inflammatory treatment, as well as in 20 healthy individuals. Statistical analyses revealed a significant difference in the levels of pro-GN (5.
View Article and Find Full Text PDFArticle Synopsis
- TNFαI therapy leads to significant improvements in joint health, physical function, and quality of life in rheumatoid arthritis (RA) patients, but its exact mechanism is still unclear.
- A 15-month study on female RA patients showed that TNFαI treatment reduced certain biomarkers of cartilage turnover, indicating a positive effect on cartilage health.
- The findings suggest that monitoring specific cartilage-related markers can be useful in assessing treatment response and managing RA effectively.
Article Synopsis
- The research aimed to identify new biomarkers for diagnosing and monitoring ulcerative colitis (UC), focusing on proteins related to intestinal barrier function and inflammation.
- Serum levels of proguanylin (pro-GN), S100A12, and pentraxin 3 (PTX3) were significantly different in UC patients compared to healthy individuals, indicating their potential as biomarkers.
- After a year of biological treatment with adalimumab, changes in pro-GN and PTX3 levels showed correlations with disease activity, highlighting their relevance in clinical settings for UC management.