Publications by authors named "A Joseph Rastegar"
Objective: This study aimed to externally validate the Preeclampsia Integrated Estimate of Risk (fullPIERS) risk prediction model in a cohort of pregnant individuals with preeclampsia in the United States.
Study Design: This was a retrospective study of individuals with preeclampsia who delivered at 22 weeks or greater from January 1, 2010, to December 31, 2020. The primary outcome was a composite of maternal mortality or other serious complications of preeclampsia occurring within 48 hours of admission.
Human health is being increasingly exposed to fluoride and nitrate ingestion globally due to anthropogenic alternations in groundwater resources. In the present research work, a hazard quotient (HQ), Monte Carlo simulation (MCS), and geographic information systems (GIS) have been used to estimate the non-carcinogenic health risk of nitrate and fluoride in vulnerable adults, teenagers, and children living in far-flung areas of Uttar Pradesh, Northern India. About 110 samples from some nearby populations were collected and analyzed for nitrates by ion chromatography and fluoride by a fluoride-selective electrode.
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- Autoimmune polyendocrine syndrome type 1 (APS-1) is a severe genetic disorder resulting from AIRE deficiency, leading to self-reactive T cells causing autoimmune damage in various organs.
- The study investigated the role of interferon-γ in APS-1 by analyzing patient samples and conducting experiments with mice, finding that high levels of interferon-γ correlate with disease activity.
- Treatment with the JAK inhibitor ruxolitinib significantly reduced interferon-γ levels and improved symptoms in APS-1 patients, suggesting that targeting this pathway may be a viable therapeutic approach.
Background: Mentha longifolia L. is a perennial plant belonging to the Lamiaceae family that has a wide distribution in the world. M.
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