Publications by authors named "A John Yucel"
Background: Beta-thalassemias (BTs) are characterized by deficient or absent synthesis of the beta-globin subunit, leading to anemia. Patient characteristics and treatment patterns in these patients may vary.
Objective: This retrospective study evaluated demographics, clinical characteristics, and treatment patterns in patients with transfusion-dependent BT (TDT) and non-transfusion-dependent BT (NTDT).
Objectives: To estimate thresholds for defining meaningful within-patient improvement from baseline to weeks 13-24 and interpreting meaningfulness of between-group difference for the non-transfusion-dependent beta-thalassaemia patient-reported outcome (NTDT-PRO) tiredness/weakness (T/W) and shortness of breath (SoB) scores. A secondary objective was to determine the symptom severity threshold for the NTDT-PRO T/W domain to identify patients with symptomatic T/W.
Design: Pooled blinded data from the phase 2, double-blind, placebo-controlled, randomised BEYOND trial in NTDT (NCT03342404) were used.
Background: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disease characterized by fever, rash, arthritis, and multi-organ involvement. Macrophage activation syndrome (MAS), a serious complication of AOSD, poses significant diagnostic and therapeutic challenges.
Case Presentation: A 32-year-old male was diagnosed with AOSD in 2020 after being hospitalized for a fever of unknown origin and elevated liver enzymes.
Evaluation of nasal mucociliary clearance in patients with psoriasis.
Eur Arch Otorhinolaryngol
October 2024
Purpose: Psoriasis is an autoimmune pathology characterized by chronic inflammation with known multiorgan involvement. In the literature, there are few studies investigating the effects of psoriasis on upper respiratory tract mucosa. Our aim in our study was to investigate the possible effect of psoriasis disease severity and duration on nasal mucosa.
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- β-Thalassemia is a lifelong inherited blood disorder that requires ongoing management and leads to significant indirect costs and a burden on patients and caregivers.
- The study conducted a systematic review of the literature from 2010 to 2020, including 75 publications, to assess health-related quality of life (HRQoL) and costs associated with the condition.
- Results showed that patients lose an average of 15.6 to 35 days yearly due to transfusion-related absenteeism, and those with non-transfusion-dependent β-thalassemia experience worse HRQoL compared to those with transfusion-dependent forms, highlighting a need for better treatments.