Publications by authors named "A John Richards"
Background: The relationships of left atrial (LA) dysfunction with cognition are poorly understood. We investigated the associations of LA function with cognitive impairment, etiologic-subtype (neurodegenerative vs. vascular[VCI]), neuroimaging markers of cerebrovascular disease (CeVD) and circulating biomarkers, in subjects without AF.
View Article and Find Full Text PDFBackground: The prognostic performance of plasma proteomics for longitudinal changes in (i)cognition (ii)neuropsychiatric symptomatology and (iii)neuroimaging outcomes within South East Asia, where prevalence of cerebrovascular disease is high, remains un-investigated.
Methods: A prospective cohort of Singaporean memory clinic attendees was followed-up for 4 years. Annual neurocognitive and neuropsychiatric assessments were performed alongside 2-yearly brain magnetic resonance imaging (MRI) scans.
Unlabelled: Crosstalk between autophagy, host cell death, and inflammatory host responses to bacterial pathogens enables effective innate immune responses that limit bacterial growth while minimizing coincidental host damage. ( ) thwarts innate immune defense mechanisms in alveolar macrophages (AMs) during the initial stages of infection and in recruited bone marrow-derived cells during later stages of infection. However, how protective inflammatory responses are achieved during infection and the variation of the response in different macrophage subtypes remain obscure.
View Article and Find Full Text PDFPurple Tea (Camellia sinensis var. assamica) Leaves and Obesity Management: A Review of 1,2-Di-Galloyl-4,6-Hexahydroxydiphenoyl-β-D-Glucose's (GHG) Potential Health Benefits, and Future Prospects.
Cureus
December 2024
Article Synopsis
- Purple tea contains bioactive compounds like caffeine, catechins, and a unique compound called GHG, which shows promise in helping manage obesity by potentially reducing BMI and body weight.
- A systematic literature review was conducted, yielding 246 articles, with 173 retained, to examine the effects of GHG on obesity through mechanisms such as inhibiting fat absorption and preventing fat formation.
- Current findings suggest that consuming purple tea extracts rich in GHG can lead to notable reductions in BMI and body weight, along with additional metabolic benefits, though further research is necessary to confirm optimal dosage and long-term effects.