[Is alfalfa hay an alternative to meadow hay in equine nutrition?].

Roughage alternatives for equine nutrition must be found due to the increasing climatic challenges. The aim of this study was to examine the nutrient composition and feed hygiene of alfalfa hay in comparison to meadow hay and to investigate the acceptance, weight development and faecal quality of broodmares fed alfalfa hay. The feed used was examined for nutrient content and hygiene status according to the standards of the Verband Deutscher Landwirtschaftlicher Untersuchungs- und Forschungsanstalten (VDLUFA).

Variants at the MHC Region Associate With Susceptibility to Infection: A Genome-Wide Association Study Using Comprehensive Electronic Health Records.

Background: is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to infection has not been studied on a large-scale.

Methods: A total of 1,160 infection cases and 15,304 controls were identified by applying the eMERGE infection algorithm to electronic health record data.

Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.

Mechanisms of hippocampus-related memory formation are time-of-day-dependent. While the circadian system and clock genes are related to timing of hippocampal mnemonic processes (acquisition, consolidation, and retrieval of long-term memory [LTM]) and long-term potentiation (LTP), little is known about temporal gating mechanisms. Here, the role of the neurohormone melatonin as a circadian time cue for hippocampal signaling and memory formation was investigated in C3H/He wildtype (WT) and melatonin receptor-knockout ( ) mice.

Single punch, double biopsy.

Objective: In lethal primary metastatic prostate cancer, biopsy material is often the only accessible cancer tissue. Lack of tissue quantity limited the use of biopsy cores for analyzing higher numbers of molecular markers and standard histopathologic evaluation for clinical diagnosis simultaneously. Recent advances in single cell analytics have paved the way to characterize a tumor in more depth from minute input material such as biopsies.

Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK.

Memory performance varies over a 24-h day/night cycle. While the detailed underlying mechanisms are yet unknown, recent evidence suggests that in the mouse hippocampus, rhythmic phosphorylation of mitogen-activated protein kinase (MAPK) and cyclic adenosine monophosphate response element-binding protein (CREB) are central to the circadian (~ 24 h) regulation of learning and memory. We recently identified the clock protein PERIOD1 (PER1) as a vehicle that translates information encoding time of day to hippocampal plasticity.