Background: Adrenocortical cancer (ACC) is rare and aggressive, with YAP1 overexpression associated with poor outcomes in pediatric patients. In this study, we investigated the mechanisms by which YAP1 drives ACC progression and explored it as a potential target therapy.
Methods: YAP1 expression and methylation in ACC were analyzed from pediatric and adult cohorts.
In the United States, there is expected to be about 82,000 cases of renal cell carcinoma (RCC) in 2024. At diagnosis, approximately 65% of patients with RCC will have disease localized to the kidney. For decades, the standard of care for patients with localized RCC has been surgery, which is often curative, followed by radiographic surveillance.
View Article and Find Full Text PDFThe crop system of soybean (summer)-maize (fall/winter) succession has been adopted widely in the Neotropics. It inadvertently provides food to stink bugs between crops, forming "green-bridges," which favor Diceraeus melacanthus (Dallas) outbreaks. Attempts to control these outbreaks, usually occurring at the end of the soybean cycle and the beginning of the maize cycle, were made by spraying insecticides at the time of soybean desiccation in addition to insecticide seed treatment on maize, but apparently it has been insufficient to provide acceptable control.
View Article and Find Full Text PDFThe use of egg parasitoids in Augmentative Biological Control (ABC) is a highly effective strategy within the integrated pest management (IPM) of lepidopteran defoliators. Safer than chemical insecticides, these natural antagonists have demonstrated significant efficacy. and , known for their high parasitism rates, are the most extensively used and studied parasitoids for controlling economically important lepidopterous in crops such as soybean and maize.
View Article and Find Full Text PDFBackground: Cancer is an important cause of morbidity and mortality after solid organ transplants. Skin cancer is the most prevalent non-lymphoid malignancy occurring during heart transplantation follow-up. Due to the complexity of immunosuppressive therapy and the high prevalence and incidence of skin cancer in this population, dermatologists play an important role in the short and long-term follow-up of heart transplant recipients.
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