Publications by authors named "A Jayan"
Antimicrobial peptides (AMPs) are small, positively charged biomolecules produced by various organisms such as animals, microbes, and plants. These AMPs play a significant role in defense mechanisms and protect from adverse conditions. The emerging problem of drug resistance in microbes poses a global health challenge in treating diseases.
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- The study investigates immune-related adverse events (irAEs) in patients with high-risk early triple-negative breast cancer (TNBC) who were treated with pembrolizumab alongside chemotherapy.
- Out of 233 patients evaluated, 34% experienced irAEs, primarily endocrinopathies and gastrointestinal issues, with some leading to severe complications requiring hospitalization or treatment adjustments.
- The findings highlight the prevalence of these adverse events in a real-world setting and underscore the importance of monitoring long-term effects as pembrolizumab becomes more commonly used in early TNBC treatment.
Objectives: The study aimed to analyze the impact of aphasia on quality of life (QoL) in persons with ischemic stroke per radiological severity, compare equally severe but nonaphasic stroke survivors, and analyze the impact of hyperbaric oxygen therapy (HBOT) exposure Methods: Patients with first-ever middle cerebral artery (MCA) stroke were categorized by radiological severity into high, intermediate, and low Alberta Stroke Program Early CT Score (ASPECTS). The Stroke Aphasia Quality of Life (SAQoL) Scale was used for outcome analysis. Inclusion criteria were age 40-65, 12-16 months after stroke, MCA distribution, first stroke, and ischemic stroke.
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- Synthetic hematite nanoparticles are widely researched for various applications, but natural iron nanoparticles in freshwater ecosystems have been under-studied.
- A study in southern India identified natural iron nanoparticles in tropical freshwater, characterized by advanced techniques showing they exist as mesoporous, amorphous hematite microspheres.
- The presence of Bacillus cereus indicates a biogeochemical origin, enhancing understanding of these nanoparticles' ecological roles and suggesting their potential for industrial uses.