Orofacial Cleft and Mandibular Prognathism-Human Genetics and Animal Models.

Many complex molecular interactions are involved in the process of craniofacial development. Consequently, the network is sensitive to genetic mutations that may result in congenital malformations of varying severity. The most common birth anomalies within the head and neck are orofacial clefts (OFCs) and prognathism.

Unified Entrainment and Detrainment Closures for Extended Eddy-Diffusivity Mass-Flux Schemes.

We demonstrate that an extended eddy-diffusivity mass-flux (EDMF) scheme can be used as a unified parameterization of subgrid-scale turbulence and convection across a range of dynamical regimes, from dry convective boundary layers, through shallow convection, to deep convection. Central to achieving this unified representation of subgrid-scale motions are entrainment and detrainment closures. We model entrainment and detrainment rates as a combination of turbulent and dynamical processes.

Long term effect of spa therapy combined with patient education program on subjects with overweight and obesity - A controlled study.

The aim of this single center prospective controlled study in volunteers with obesity and overweight was to evaluate the effect of a patient therapeutic education program (PTE group) combined with spa therapy on weight, physical activity, eating habits and quality of life versus spa therapy alone (control group). The main endpoint was weight change at 5 months after the end of the program. The PTE group of 151 subjects with obesity or overweight followed a 3-week program combining patient education with spa therapy and 189 attended a course of spa therapy alone.

H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy.

Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer. The aim of this review is to analyze and discuss the newest findings regarding the role of H3K18Ac and acetylation of other histones in carcinogenesis.

Novel Mutation of the Gene in Patients with Cleidocranial Dysplasia.

Cleidocranial dysplasia (CCD) is an autosomal dominant disorder linked to mutations in the Runt-related transcription factor 2, encoded by the gene, which is essential for osteoblast differentiation and skeletal development. Here, we describe a novel nonsense mutation (c.532C>T; p.