Publications by authors named "A Jannin"
Preoperative treatment of PHPT aims to 1) manage severe and/or symptomatic hypercalcemia and 2) prevent postoperative hypocalcemia. Severe hypercalcemia, defined as a blood calcium level ≥ 3.5 mmol/L, requires admission to hospital in a conventional or critical care unit, depending on clinical symptoms and comorbidities.
View Article and Find Full Text PDFLATEST DEVELOPMENTS IN ANAPLASTIC THYROID CARCINOMA MANAGEMENT IN 2024: Anaplastic thyroid carcinomas (ATCs) represent a rare and undifferentiated form of thyroid cancer with a poor prognosis, typically marked by a median overall survival of four to ten months. However, recent advances have shown improvements due to the more systematic application of molecular testing, targeted therapies, and immunotherapy, alongside the establishment of rapid specialized care protocols in expert centers. Clinically, ATCs often present as a rapidly enlarging cervical mass originating from the thyroid, causing neck, pain and tenderness, dyspnea and dys-phagia, and associated lymphadenopathy, typically in elderly patients.
View Article and Find Full Text PDFArticle Synopsis
- * These conditions can arise in people without obesity, may have genetic links, and usually differ from lipodystrophy syndromes, which involve areas of fat loss.
- * The review discusses various forms of lipomatosis, including isolated conditions like Madelung disease and syndromic forms associated with genetic disorders, and highlights their potential impact on health and appearance.
Article Synopsis
- VIPomas are rare tumors that cause life-threatening hormonal issues by secreting vasoactive intestinal peptide (VIP), and plasma VIP can be measured to confirm diagnosis, although interference in tests can occur.
- Researchers developed three methods to detect potential interference in VIP radioimmunoassay (RIA) tests and studied both patients suspected of false positive VIP results and those with confirmed VIPomas.
- Their results showed that all false positive patients had interference in the tests, whereas no such issues were found in confirmed VIPoma patients, indicating the importance of using their developed techniques when test results don't match clinical symptoms.