Publications by authors named "A Janev"
Article Synopsis
- Birth-associated tissues and their factors, known as perinatal derivatives (PnD), show promise for treating various health conditions due to their biological properties, but their clinical use is hindered by inconsistent protocols in research.
- The paper introduces the PnD e-questionnaire, designed to evaluate existing methods for obtaining and analyzing PnD, aiming to promote standardized practices across studies.
- It also suggests essential reporting criteria for researchers to enhance transparency and reproducibility, ultimately supporting the transition of PnD research from the lab to clinical applications.
Article Synopsis
- Bladder cancer is a prevalent type of cancer with significant treatment costs, and research is focusing on the human amniotic membrane (hAM) for its potential anticancer benefits.
- Studies show that hAM extracts can inhibit key markers related to cancer progression and migration in bladder cancer cells, indicating a dose-dependent effect on these processes.
- The findings suggest that hAM's ability to downregulate important cancer-related signaling pathways could lead to new therapeutic strategies and support ongoing drug development efforts.
Despite being among the ten most common cancers with high recurrence rates worldwide, there have been no major breakthroughs in the standard treatment options for bladder cancer in recent years. The use of a human amniotic membrane (hAM) to treat cancer is one of the promising ideas that have emerged in recent years. This study aimed to investigate the anticancer activity of hAM homogenate on 2D and 3D cancer models.
View Article and Find Full Text PDFUrinary tract infections (UTIs) represent a serious global health issue, especially due to emerging multidrug-resistant UTI-causing bacteria. Recently, we showed that the human amniotic membrane (hAM) could be a candidate for treatments and prevention of UPEC and infections. However, its role against multidrug-resistant bacteria, namely methicillin-resistant (MRSA), extended-spectrum beta-lactamases (ESBL) producing and , vancomycin-resistant (VRE), carbapenem-resistant , and has not yet been thoroughly explored.
View Article and Find Full Text PDFProgress in the understanding of the biology of perinatal tissues has contributed to the breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth-associated tissues, cells, and secreted factors. The significant knowledge acquired in the past two decades, along with the increasing interest in perinatal derivatives, fuels an urgent need for the precise identification of PnD and the establishment of updated consensus criteria policies for their characterization. The aim of this review is not to go into detail on preclinical or clinical trials, but rather we address specific issues that are relevant for the definition/characterization of perinatal cells, starting from an understanding of the development of the human placenta, its structure, and the different cell populations that can be isolated from the different perinatal tissues.
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