Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer's model.

Background: Alzheimer's disease (AD) remains incurable, yet its long prodromal phase offers a crucial window for early intervention. Pretangle tau, a precursor to neurofibrillary tangles, plays a key role in early AD pathogenesis. Intervening in pretangle tau pathology could significantly delay the progression of AD.

Invasive pneumococcal disease in adults after the introduction of pneumococcal vaccination: a retrospective study in the metropolitan area of Zagreb, Croatia (2010-2022).

Introduction: Invasive pneumococcal disease (IPD) is a severe form of illness caused by with high morbidity and mortality rate in the general population, particularly in children <5 years of age, adults ≥65 years of age and the immunocompromised. As known, pneumococcal vaccination lowers the risk of IPD so the aim of this study was to investigate whether the introduction of pneumococcal vaccination has influenced the incidence and mortality of IPD in adults in Croatia.

Materials And Methods: A retrospective study was conducted among adult patients (aged ≥18 years) hospitalized due to IPD in the metropolitan area of Zagreb from 1 January 2010 to 31 December 2022.

Catecholaminergic Modulation of Large-Scale Network Dynamics Is Tied to the Reconfiguration of Corticostriatal Connectivity.

Large-scale brain network function is critical for healthy cognition, yet links between such network function, neurochemistry, and smaller-scale neurocircuitry are unclear. Here, we evaluated 59 healthy individuals using resting-state fMRI to determine how network-level temporal dynamics were impacted by two well-characterized pharmacotherapies targeting catecholamines: methylphenidate (20 mg) and haloperidol (2 mg)-administered via randomized, double-blind, placebo-controlled design. Network temporal dynamic changes were tested for links with drug-induced alterations in complex corticostriatal connections as this circuit is a primary site of action for both drugs.

Predictive Strength of Auditory Maturity Across Different Levels of Language Ability: An Exploratory Quantile Regression Study.

Auditory evoked potential-age (AEP-age) is proposed to index auditory maturation and has been found to predict language skills in children with and without a language disorder. However, reporting average effects using linear regression does not fully capitalize on the potential of AEP-age to estimate individual differences in young children. This study used a quantile regression approach to examine the predictive utility of AEP-age for 105 typical and neurodiverse 7-10-year-old children (61 males; 44 females; largely monolingual English) with varying language skills without creating subgroups.

Detection of Lowering in Sport Climbing Using Orientation-Based Sensor-Enhanced Quickdraws: A Preliminary Investigation.

Climbing gyms aim to continuously improve their offerings and make the best use of their infrastructure to provide a unique experience for their clients, the climbers. One approach to achieve this goal is to track and analyze climbing sessions from the beginning of the ascent until the climber's descent. Detecting the climber's descent is crucial because it indicates when the ascent has ended.