Publications by authors named "A James D'Silva"
: Porcine Circovirus 2 (PCV2) infection poses significant health and economic challenges to the global swine industry. The disease in pigs leads to lymphoid depletion, resulting in immunosuppression and increased susceptibility to co-infections with other bacterial and viral pathogens. This study evaluated the efficacy of two novel recombinant Newcastle disease virus (NDV) strain R2B vectored vaccines that express the cap gene of PCV2 alone and along with the transmembrane and cytoplasmic tail (TMCT) domains of the NDV F gene.
View Article and Find Full Text PDFIntroduction: Digital health tools can be beneficial in the care of patients with chronic conditions and have the potential for widespread impact as readily scalable and cost-effective health interventions. However, benefits are often contingent on users sustaining their engagement with these tools over time. Sustained engagement with digital health tools can be challenging, and high rates of attrition from digital interventions are common.
View Article and Find Full Text PDFKetogenic diet therapy (KDT) is an established treatment for people with epilepsy. As increasing evidence demonstrates effectiveness and safety of KDT on seizure reduction, cognition and behaviour, it is essential to evaluate factors hindering and supporting neurologists in prescribing KDT to strengthen quality, evidence-based, appropriate and equitable care. A study of Australian and New Zealand (ANZ) neurologists was undertaken via an online survey.
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- Digital health interventions (DHIs) show promise for helping patients with irritable bowel syndrome (IBS) manage their symptoms, but there is a lack of research on their effectiveness.
- A systematic review analyzed 13 studies focused on DHIs for IBS, highlighting their positive impacts on symptom severity and quality of life, particularly those targeting brain-gut behaviors and health monitoring.
- While the DHIs were generally well-received, the review calls for more research on their feasibility, safety, and overall efficacy to better support IBS patients.
Background: Medications form the basis of treatment for heart failure (HF) and adherence is crucial as untreated HF has a mortality of greater than 30%. As such, specialist HF pharmacists with expertise in prescribing and promoting adherence have become an integral part of the wider HF multidisciplinary team (MDT).
Aim: To implement specialist HF pharmacist prescribing clinics and evaluate their impact.