Publications by authors named "A Jambor"

Article Synopsis
  • Transcription factors (TFs) play a crucial role in determining different T cell states, particularly in contexts like viral infections and cancer, leading to the creation of a detailed atlas of nine CD8 T cell differentiation states for predicting TF activity.
  • The study highlights the functional contrast between terminally exhausted T cells (TEX), which are dysfunctional, and tissue-resident memory T cells (T), which provide protection, while emphasizing the challenges in selectively promoting the beneficial state without allowing TEX differentiation.
  • Using techniques like CRISPR screening and single-cell RNA sequencing, researchers identified specific TFs linked to TEX state differentiation, discovered new TEX-specific TFs, and established potential targets for enhancing tumor control by improving T cell functionalities.
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Article Synopsis
  • Driving under the influence of drugs (DUID) is risky and depends on when you take them, how much, and how they interact with other drugs.
  • A study in Hungary from 2016 to 2018 found that 95% of drivers tested positive for at least one drug, with cannabis and amphetamines being the most common.
  • Many drivers showed signs of being impaired (69%), and there were changes in drug use patterns, including a decrease in new psychoactive substances and an increase in synthetic cannabinoids.
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Charting the long-term trends in European wheat and maize yields and harvested areas and the relation of yields to climatic and economic drivers, two profound spatial processes become apparent. One consequence of the relatively late modernization of Eastern Europe has been to shift the focus of grain production from West to East. The warming trend prevailing over the past decades in the summer and winter seasons has been accompanied by a South to North shift in the harvested areas.

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Construction of nitrogen-nitrogen triple bonds via homocoupling of metal nitrides is an important fundamental reaction relevant to a potential . Here, we report that room temperature photolysis of Ru(chp)N (chp = 2-chloro-6-hydroxypyridinate) in CHCl produces N via reductive coupling of Ru(chp)N nitrido species. Computational analysis reveals that the nitride coupling transition state (TS) features an out-of-plane "zigzag" geometry instead of the anticipated planar zigzag TS.

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Introduction: Structural changes in the collagen II architecture of osteoarthritis (OA) are poorly understood, which is a large shortcoming in the early diagnosis of this disease. Though degradation can be simulated by enzymes including trypsin and bacterial collagenase, the specific structural features of each digestion and their relationship to naturally occurring OA remain unclear.

Experimental Design: We used collagen sensitive/specific Second Harmonic Generation (SHG) microscopy in conjunction with optical scattering measurements to probe the resulting architecture changes in bovine knee cartilage upon trypsin and collagenase degradation.

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