Publications by authors named "A Jalanko"
Article Synopsis
- The TWINGEN study aims to identify individuals at high risk for Alzheimer's disease (AD) by assessing various cognitive and health-related factors through an observational clinical recall and biomarker analysis.
- The study involves around 800 participants, gathering data through blood samples, questionnaires, and wearable technology for lifestyle metrics, while also including a smaller group for in-person assessments.
- All data collected will be integrated with existing Finnish biobank records and utilized for further research, following ethical guidelines set by relevant authorities.
Introduction: A better understanding of the earliest stages of Alzheimer's disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers.
View Article and Find Full Text PDFArticle Synopsis
- Population isolates like Finland provide a unique advantage for genetic research by having concentrated deleterious alleles in low-frequency variants due to historical bottlenecks.
- The FinnGen study aims to analyze data from 500,000 Finnish individuals, focusing on their genomes and health records, particularly as many participants are older and have disease-related data.
- From the analysis of 224,737 participants and additional biobank data, researchers discovered 30 new associations and a total of 2,733 significant genetic links across various diseases, highlighting the importance of low-frequency variants in understanding common diseases.