Publications by authors named "A J van der Vlies"
Nanoparticles of zeolitic imidazole framework-8 (ZIF-8 NPs), which are the subclass of metal-organic frameworks consisting of Zn ion and 2-methylimidazole, have been identified as promising drug carriers since their large microporous structure is suited for encapsulating hydrophobic drug molecules. However, one of the limitations of ZIF-8 NPs is their low stability in physiological solutions, especially in the presence of water and phosphate anions. These molecules can interact with the coordinatively unsaturated Zn sites at the external surface to induce the degradation of ZIF-8 NPs.
View Article and Find Full Text PDFObjectives: We aimed to compare and link the total scores of the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), two common global cognitive screeners.
Methods: 2,325 memory clinic patients (63.2 ± 8.
Objective: We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of dementia and how it relates to AD pathology.
Methods: 3,599 patients (63.9 ± 8.
Recent advance in self-assembled polymeric nanomedicines for gaseous signaling molecule delivery.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
March 2024
Gaseous signaling molecules such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H S) have recently been recognized as essential signal mediators that regulate diverse physiological and pathological processes in the human body. With the evolution of gaseous signaling molecule biology, their therapeutic applications have attracted growing attention. One of the challenges in translational research of gaseous signaling molecules is the lack of efficient and safe delivery systems.
View Article and Find Full Text PDFArticle Synopsis
- Polymeric nanoparticles with reactive functional groups can effectively carry drugs due to their ability to form covalent linkages, necessitating methods for modifying the nanoparticles to include various functional groups.
- The research introduces phenylboronic acid (PBA)-containing nanoparticles (BNP) that have a high surface area and unique shape, allowing them to bind with drugs like curcumin and donor molecules, enhancing their drug delivery potential.
- A novel method involving a palladium-catalyzed reaction allows for the efficient addition of functional groups to BNPs in water, leading to successful drug conjugation without altering their structure, demonstrated by the combination with a hydrogen sulfide-releasing compound.