Publications by authors named "A J van der Molen"
The risk of developing a severe delayed cutaneous reaction (SCAR) is very low following iodine-based contrast medium (ICM) administration and extremely low following gadolinium-based contrast agent (GBCA) administration. However, SCAR can be very severe and potentially life-threatening. It is crucial for the imaging physician to recognize danger signals: bullous skin eruption, skin erosion and detachment, mucosal involvement, systemic symptoms, and laboratory abnormalities.
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- The Gadolinium Research and Education Committee (GREC) monitors and improves the safety and effectiveness of gadolinium-based contrast agents (GBCAs) used in MRI, emphasizing the need for alternatives and careful dosage.
- GBCAs are crucial for enhancing MRI images and clinical decision-making, and guidelines recommend their use only when necessary and at the lowest effective dose.
- The article discusses evaluating GBCA use in terms of cost-effectiveness, environmental impact, and the benefits of emerging next-generation GBCAs, which promise better stability and effectiveness at reduced doses.
The risk of hypersensitivity reactions (HSR) following nonvascular administration of contrast media (CM) for diagnostic studies is very low, likely due to minimal absorption into the systemic circulation. Most published individual cases of HSR after nonvascular CM administration are immediate reactions caused by ionic high-osmolar CM, few by nonionic low-osmolar CM, and none by gadolinium-based contrast agents. Measures to prevent recurrent HSR following nonvascular administration are similar to those recommended to prevent HSR after intravascular CM administration.
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