Publications by authors named "A J van Wijnen"
Multipotent bone marrow mesenchymal stromal/stem cells (MSCs) respond to mechanical forces. MSCs perceive static and dynamic forces through focal adhesions, as well as cytoskeletal and intranuclear actin. Dynamic strain stimulates nuclear β-catenin (Ctnnb1) that controls gene expression and suppresses osteogenesis.
View Article and Find Full Text PDFThe CRISPR/Cas9 system is a powerful tool for genome editing, utilizing the Cas9 nuclease and programmable single guide RNA (sgRNA). However, the Cas9 nuclease activity can be disabled by mutation, resulting in catalytically deactivated Cas9 (dCas9). By combining the customizable sgRNA with dCas9, researchers can inhibit specific gene expression (CRISPR interference, CRISPRi) or activate the expression of a target gene (CRISPR activation, CRISPRa).
View Article and Find Full Text PDFArticle Synopsis
- * This review examines how changes in the function of KAT3A and KAT3B are linked to neurodegenerative diseases like Huntington's and Alzheimer's, emphasizing their roles in chromatin regulation and cellular signaling pathways.
- * The research highlights the importance of the KAT3 proteins in maintaining cellular function and suggests that understanding their regulatory processes could lead to new discoveries in neurodevelopment and treatments for neurodegenerative disorders.