Publications by authors named "A J deMello"

In situ monitoring is essential for catalytic process design, offering real-time insights into active structures and reactive intermediates. Electron paramagnetic resonance (EPR) spectroscopy excels at probing geometric and electronic properties of paramagnetic species during reactions. Yet, state-of-the-art liquid-phase EPR methods, like flat cells, require custom resonators, consume large amounts of reagents, and are unsuited for tracking initial kinetics or use with solid catalysts.

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Article Synopsis
  • The measurement of mechanical properties between cancer and benign cells can aid in disease detection and classification, but current methods struggle with high-throughput evaluations in clinical settings.!* -
  • A new ultrahigh-throughput viscoelastic microfluidic platform allows for single-cell mechanical property measurements at speeds of up to 100,000 cells per second, addressing the need for faster diagnostic techniques.!* -
  • This platform has demonstrated utility in analyzing tumor biopsies, studying drug effects on cell structures, and identifying cancerous lymphocytes in blood samples, paving the way for improved clinical diagnostics and personalized medicine.!*
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Cells can dynamically organize reactions through the formation of biomolecular condensates. These viscoelastic networks exhibit complex material properties and mesoscale architectures, including the ability to form multiphase assemblies. It was shown previously that condensates with complex architectures may arise at equilibrium in multicomponent systems or in condensates that were driven out of equilibrium by changes in external parameters such as temperature.

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Cell-cell interactions are essential for the proper functioning of multicellular organisms. For example, T cells interact with antigen-presenting cells (APCs) through specific T-cell receptor (TCR)-antigen interactions during an immune response. Fluorescence-activated droplet sorting (FADS) is a high-throughput technique for efficiently screening cellular interaction events.

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