Transcoronary cooling and dilution for cardioprotection during revascularisation for ST-segment elevation myocardial infarction: design and rationale of the STEMI-Cool study.

Background: ST-segment elevation myocardial infarction (STEMI) is treated with immediate primary percutaneous coronary intervention (pPCI) to restore coronary blood flow in the acutely ischaemic territory, but is associated with reperfusion injury limiting the benefit of the therapy. No treatment has proven effective in reducing reperfusion injury. Transcoronary hypothermia has been tested in clinical studies and is well tolerated, but is generally established after crossing the occlusion with a guidewire therefore after initial reperfusion, which might have contributed to the neutral outcomes.

A Comprehensive Review of the Antimicrobial Effects of Hibiscus Species.

Hibiscus, particularly , is a flowering plant known for its bright red calyxes and diverse uses in traditional medicine. Historically, cultures throughout Africa, Asia, and the Caribbean have utilized hibiscus for its health benefits, including its role in treating high blood pressure, digestive problems, and skin conditions. The rich phytochemical profile of hibiscus, particularly its high content of anthocyanins and flavonoids, has attracted increasing scientific interest, particularly with regard to its antimicrobial properties.

Potential Association of Maker Expression of Low-Density Neutrophils and Their Phenotypes in Patients with Periodontitis: Control Study.

Background: Neutrophils play an important role in maintaining periodontal status in conditions of healthy homeostasis. They achieve their surveillance function by continuously migrating to the gingival sulcus and eradicating periodontal pathogens. In addition, neutrophils are considered an integral element in the pathogenesis of periodontal diseases.

Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents.

The management of inflammatory bowel disease (IBD) in children and adolescents is challenging. Clear evidence-based guidelines are required for this population. This article provides recommendations for managing IBD in Saudi children and adolescents aged 6-19 years, developed by the Saudi Ministry of Health in collaboration with the Saudi Society of Clinical Pharmacy and the Saudi Gastroenterology Association.