Publications by authors named "A J Willig"
Background: People with HIV (PWH) have benefited greatly from antiretroviral therapy, but face additional challenges from age-related comorbid conditions, particularly cardiovascular disease including venous thromboembolism (VTE). Little is known about the effect of HIV viremia and immunodeficiency on VTE risk in this population.
Methods: We assessed incident, centrally adjudicated VTE among 21,507 PWH in care between 1/2009-12/2019 within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort.
Article Synopsis
- - This study investigates the link between alcohol consumption and falls among people with HIV (PWH), highlighting that falls are a major health issue, especially for older adults and PWH.
- - Researchers categorized participants (315 PWH, mostly male, average age 52) into drinking levels (none, non-hazardous, hazardous) and analyzed the relationship between their drinking habits and fall incidents using various statistical methods.
- - Findings revealed that hazardous drinkers had a significantly higher risk of falls and recurrent falls compared to non-hazardous drinkers, but the amount of alcohol consumed daily in grams did not show a clear connection to fall risk.
Substance use is associated with decreased antiretroviral therapy (ART) adherence among people with HIV (PWH). Adherence plays a significant role in mediating the negative effects of substance use on HIV suppression and is a principal modifiable patient-level factor in improving HIV suppression and reducing ART drug resistance. Understanding substance use and ART adherence, particularly with rapidly changing substance use epidemiology and ART regimens, is vital to improving HIV care.
View Article and Find Full Text PDFBackground: Frailty occurs at higher rates and younger ages among people with HIV (PWH) compared to the general population and is often attributed to chronic inflammation and subsequent immune exhaustion. We assessed how inflammatory biomarkers are associated with frailty among PWH.
Methods: The Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort is comprised of adult PWH in care at 10 sites, and harmonizes demographic, clinical, and patient-reported outcomes (PRO) data.