Background: Early child development sets the course for optimal outcomes across life. Increasing numbers of children worldwide are exposed to opioids in pregnancy and frequently live in environments associated with adverse developmental outcomes. Although multiple systematic reviews have been published in this area, they use different exposures and different types of outcomes.
View Article and Find Full Text PDFThe anti-cancer potential of eugenol (EUG) is well recognized, whereas that of spermidine (SPD) is subject to dispute and requires further research. The anti-tumorigenic potential of wheat germ SPD (150 µM) and clove EUG (100 µM), alone, in combination as SPD+EUG (50 µM + 100 µM) and, as a supplement (SUPPL; 0.6 µM SPD + 50 µM EUG), was investigated on both metastatic SW620 and primary Caco-2 colorectal cancer (CRC) spheroids.
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) with highly malignant and aggressive, still faces challenges in treatment due to the single treatment and side effects. It is urgent to develop an advanced theranostic platform against TNBC. Herein, an "all-in-one" nano-system Au/Cu nanodots/doxorubicin@nanospheres (Au/CuNDs/DOX@NS) with dual-responsive properties was designed for dual-mode imaging-guided combination treatment of TNBC.
View Article and Find Full Text PDFObjective: This study used the Midlife-Development in the United States (MIDUS) dataset to a) examine relationships between reported childhood adversity (CA), anxiety, and pain; b) assess associations between CAs, anxiety, C-reactive protein (CRP) levels, and pain; and c) explore how CAs, anxiety, and CRP are associated with pain medication consumption.
Methods: Data were from Project-4 of MIDUS-II (n = 1225), which utilized Project-1 demographics and supplemental chart review. For objectives 1-2, structural equational modeling (SEM) followed by general linear modeling (GLM) regression was conducted.