Publications by authors named "A J Wenzel"
An auxiliary-based protocol is described for an asymmetric allenoate Claisen rearrangement. Silicated tosic acid (10 mol %) was used as an inexpensive, user-friendly catalyst. Stereochemical analysis revealed a preferential attack at the face of prostereogenic olefin.
View Article and Find Full Text PDFPurpose: Conventional image-guided radiotherapy (IGRT) of the prostate bed is challenged by the varying anatomy due to dynamic changes of surrounding organs such as the bladder and rectum. This leads to changed dose coverage of target and surrounding tissue. The novel online adaptive radiotherapy (oART) aims to improve target coverage as well as reduce dose exposure to surrounding healthy tissues by daily reoptimization of treatment plans.
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- This study examined the connection between two imaging techniques, Quantitative Susceptibility Mapping (QSM) and Transcranial Sonography (TCS), to evaluate iron levels in the substantia nigra of patients with Parkinson's disease (PD).
- Eighteen imaging sessions were conducted on 15 PD patients, revealing strong correlations between nigral iron susceptibility and TCS measurements of echogenicity.
- The findings suggest that increased iron accumulation in the substantia nigra may contribute to the observed echogenicity in PD, with echogenicity likely reflecting stored ferritin-bound iron in microglia.
Article Synopsis
- ADHD and substance use disorder (SUD) frequently co-occur in adolescents, but existing treatment guidelines often overlook this specific group.
- The Joint Addiction Commission of the German Child and Adolescent Psychiatric Society has created recommendations to guide effective treatment practices for adolescents with both conditions.
- Early use of stimulant medications may be beneficial for adolescents diagnosed with ADHD and SUD.
Purpose: Next-generation sequencing (NGS) tools have clinical advantages over blood culture but are more expensive. This study assesses the budget impact and break-even point of NGS testing costs from a healthcare provider's perspective in Germany.
Methods: The budget impact was calculated based on aggregated data of German post-operative surgery cases.