Publications by authors named "A J Wanders"
The role of the vitamin D receptor (VDR) in inflammatory bowel disease (IBD) is poorly described. The aim of this study was to examine the relationship between immunohistochemical VDR expression and IBD activity. The immunohistochemical expression of VDR was analysed in biopsies from active and inactive IBD in 28 patients (ulcerative colitis: 21, Crohn's disease: 7) and 12 non-IBD controls.
View Article and Find Full Text PDFObjectives: Fibrosis is the final common pathway for chronic kidney disease and the best predictor for disease progression. Besides invasive biopsies, biomarkers for its detection are lacking. To address this, we used hyperpolarized 13 C-pyruvate MRI to detect the metabolic changes associated with fibrogenic activity of myofibroblasts.
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- Decitabine (5-aza-dC) is a nucleoside analogue used for treating certain blood cancers, but its effectiveness can vary and relapses are common.
- Research using CRISPR/Cas9 screens identified that the loss of the enzyme DCTD makes cancer cells resistant to decitabine by reducing the production of 5-aza-dUMP, which is toxic to cells.
- The study revealed that the protein TOPORS helps repair decitabine-induced DNA damage and may be targeted for new biomarkers to predict how patients respond to decitabine treatment.
The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and assessment of nutritional interventions as multiple aspects of metabolic health should be considered at once. Here, we apply the Mixed Meal Model, a physiology-based computational model, to characterize an individual's metabolic health A population of 342 personalized models were generated using data for individuals with overweight and obesity from three independent intervention studies, demonstrating a strong relationship between the model-derived metric of insulin resistance (ρ = 0.
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- - The study explores the potential of plant-based meat substitutes to help create more sustainable diets, highlighting the need for consumer acceptance tied to feelings of fullness or satiety.
- - Sixty adults participated in the study, consuming fixed ready-to-eat meals featuring either animal or plant-based 'meat' options in real-life home settings.
- - Results showed no significant difference in the satiating capacity of plant-based and animal meat dishes, suggesting that plant-based meals can effectively satisfy hunger just like traditional meat meals.