Background: The multi-day Boston Remote Assessment of Neurocognitive Health (BRANCH) is a remote, web-based assessment designed to capture the earliest cognitive changes in the preclinical stage of Alzheimer's disease (AD). It has been validated in unimpaired older adults, but as individuals progress on the AD continuum, assessments need to remain feasible and valid at different clinical stages. The focus of this study was to assess feasibility and validity of multi-day BRANCH in participants with and without cognitive impairment.
View Article and Find Full Text PDFBackground/objectives: We analyzed the relationship between synapsis, recombination, and transcription during the spermatogenesis of the grasshopper carrying B chromosomes (type B1).
Methods: The progression of synapsis was interpreted according to the dynamics of the cohesin subunit SMC3 axes. DNA double-strand breaks were revealed by RAD51 immunolabeling, while transcriptional activity was determined by the presence of RNA polymerase II phosphorylated at serine 2 (pRNApol II) immunolabeling.
Introduction: This narrative review aims to identify and explore the social determinants that prevent people living with HIV (PWH) from accessing specialized cancer centers in the United States and compare to patient experiences in other countries.
Methods: The review includes randomized controlled trials, cohort studies, case-control studies, qualitative studies, case series, and non-peer reviewed articles. The risk of bias was assessed using standardized tools, and data were synthesized narratively due to the heterogeneity of study designs and outcomes.
Background: Contingency management (CM), an incentive-based intervention to encourage target behaviors, effectively promotes medication adherence. However, efforts to extend CM to HIV pre-exposure prophylaxis (PrEP) have been lacking. As part of a randomized clinical trial to promote HIV Prevention among people who inject drugs (PWID), we examined the readiness of staff in community-based organizations serving PWID to implement CM for PrEP uptake and adherence in this population.
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