Publications by authors named "A J Van der Kogel"
Aims: Exercise-induced cellular stress and sterile inflammation are of increasing interest. ASC specks are a component of the intracellular NLRP3-inflammasome and can be released into the blood. For example, serum ASC specks are increased after marathon running.
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- Cognitive impairment is a significant issue in myelin oligodendrocyte glycoprotein-IgG-associated disease (MOGAD), with a study showing that about 21.9% of patients experience cognitive deficits, particularly in mental flexibility and attention.
- The study involved 32 MOGAD patients and analyzed clinical factors like age and previous relapses, finding that the overall number of relapses and past episodes of acute disseminated encephalomyelitis (ADEM) were linked to increased cognitive impairment risk.
- MRI results indicated that patients with MOGAD had reduced white and deep gray matter volumes compared to healthy controls, highlighting potential neurological damage in this condition.
Article Synopsis
- - The study focuses on the relationship between mRNA translation and decay in human cells, specifically highlighting the role of the cytoplasmic exosome in degrading mRNA linked to ribosomes during quality control.
- - Researchers identified that HBS1L3 (SKI7) facilitates a direct physical coupling between EXO10 and the ribosome-bound SKI238 complex, enabling efficient mRNA handover for degradation.
- - They discovered that the decay process involves a supercomplex formed by the exosome and ribosome, allowing mRNA to be efficiently threaded from the ribosome through the helicase to the exoribonuclease, effectively coordinating the decay mechanism.
NLRP3 inflammasome-induced pyroptosis and serum ASC specks are increased in patients with cardiogenic shock.
Am J Physiol Heart Circ Physiol
October 2024
Cardiogenic shock (CS) is characterized by impaired cardiac function, very high mortality, and limited treatment options. The proinflammatory signaling during different phases of CS is incompletely understood. We collected serum and plasma ( = 44) as well as freshly isolated peripheral blood mononuclear cells (PBMCs, = 7) of patients with CS complicating acute myocardial infarction on admission and after revascularization (24, 48, and 72 h) and of healthy controls (serum and plasma, = 75; PBMCs, = 12).
View Article and Find Full Text PDFObjectives: Global brain volume changes in patients with myelin oligodendrocyte glycoprotein antibody-associated disease compared with healthy controls (HC) could be revealed by magnetic resonance imaging, but specific atrophy patterns of cortical structures and relation to cognitive impairment are not yet comprehensively known. Thus, we aimed to investigate cortical thickness differences in patients with myelin oligodendrocyte glycoprotein antibody-associated disease compared with HC.
Methods: 3-Tesla brain magnetic resonance imaging was performed in 23 patients with myelin oligodendrocyte glycoprotein antibody-associated disease and 49 HC for voxel-wise group comparisons and neuropsychological testing in patients.