Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species.

The liver represents a major eliminating and detoxifying organ, determining exposure to endogenous compounds, drugs, and other xenobiotics. Drug transporters (DTs) and drug-metabolizing enzymes (DMEs) are key determinants of disposition, efficacy, and toxicity of drugs. Changes in their mRNA and protein expression levels and associated functional activity between the perinatal period until adulthood impact drug disposition.

qPCR Assays for the Detection of Cylindrocladium buxicola in Plant, Water, and Air Samples.

Cylindrocladium buxicola (syn. C. pseudonaviculatum; teleomorph Calonectria pseudonaviculata) is an important fungal pathogen of Buxus spp.

Targeted exome sequencing in clear cell renal cell carcinoma tumors suggests aberrant chromatin regulation as a crucial step in ccRCC development.

Clear cell renal cell carcinomas are characterized by 3p loss, and by inactivation of Von Hippel Lindau (VHL), a tumorsuppressor gene located at 3p25. Recently, SETD2, located at 3p21, was identified as a new candidate ccRCC tumor-suppressor gene. The combined mutational frequency in ccRCC tumors of VHL and SETD2 suggests that there are still undiscovered tumor-suppressor genes on 3p.

Prevention of coronary heart disease and osteoporosis in women aged 45 to 49 years: a challenging role for general practitioners.

Objective: Part of the risks for coronary heart disease (CHD) and osteoporosis in women are established by their lifestyle in the premenopausal period. Therefore, we assessed the risk of women aged 45 to 49 years for CHD and osteoporosis and its relation with socioeconomic status (SES) and access to general practitioners (GPs) to provide clues for prevention.

Methods: The health interview data used for this study originated from the second Dutch National Survey of General Practice, a study with a response rate of 64.