Publications by authors named "A J Valleron"
Article Synopsis
- - The age at diagnosis of Type 1 diabetes (T1D) is influenced by both the age at which autoimmune damage begins and the speed at which beta cells are destroyed, with genetics playing a key role, particularly in children.
- - A study of European children diagnosed with T1D from 1980-2008 identified 14 specific SNPs (genetic variants) associated with age at diagnosis, including new associations not found in previous studies.
- - Many of the identified genetic loci are linked to immune system functions and other autoimmune conditions, indicating that these genes may significantly contribute to the early immune processes leading to beta cell destruction in T1D.
Immunity to the SARS-CoV-2 virus ensures protection against reinfection by this virus thanks to the combined action of neutralizing antibodies and T lymphocytes specific to viral proteins, in particular the Spike protein. It must be distinguished from the immune response that ensures healing of the infection following contamination that involves innate immunity, particularly type 1 interferons, and which is followed by adaptive cellular and humoral immunity. The importance of the effect of interferons is highlighted by the occurrence of severe forms of the disease in genetically deficient subjects or in patients with antibodies neutralizing type 1 interferon.
View Article and Find Full Text PDFHypospadias (H) is a common birth defect affecting the male urinary tract. It has been suggested that exposure to endocrine disrupting chemicals might increase the risk of H by altering urethral development. However, whether H risk is increased in places heavily exposed to agricultural pesticides, such as vineyards, remains debated and difficult to ascertain.
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