Publications by authors named "A J Vallecillo"
Identifying and evaluating potential vaccine candidates has become one of the main objectives to combat tuberculosis. Among them, mannosylated Apa antigen from Mycobacterium tuberculosis and the non-mannosylated protein expressed in Escherichia coli, have been studied. Although both proteins can induce a protective response in mice, it has been considered that native protein can be dispensed.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on the role of protein methylation in the behavior of the heparin binding hemagglutinin (HbhA) from bacteria, suggesting it could serve as a candidate for a subunit vaccine due to altered immune response.
- - Researchers expressed HbhA as a recombinant methylated protein and examined its behavior under nitrogen-limiting conditions, discovering that methylation affects the protein's stability but not its interaction with certain cells.
- - The findings indicate that HbhA acts as a Fatty Acid Binding Protein, hinting at its potential role in lipid body formation related to tuberculosis and emphasizing the need for specialized expression systems to study modified proteins effectively.
Bovine neosporosis in dairy cattle from the southern highlands of Ecuador.
Vet Parasitol Reg Stud Reports
April 2020
The aim of this study was to describe bovine neosporosis in dairy cattle from the Sierra region, Ecuador. A case-control study was performed on 841 dairy cattle from 5 dairy herds. The overall seroprevalence was 23.
View Article and Find Full Text PDFPlasminogen and plasmin are fundamental components of the fibrinolytic system that interact with microorganisms generating different immunopathological effects. The molecules of Mycobacterium tuberculosis interplaying with plasminogen have already been identified and characterized. In this work, we studied the effects of plasmin(ogen) bound toMycobacterium bovisCalmette-Guérin (BCG) on phagocytosis in THP1 macrophages as well as in granuloma formation and development on in vitrohuman granuloma model.
View Article and Find Full Text PDF