Publications by authors named "A J Unsworth"
Background: The thromboxane A2 receptor (TPαR) plays an important role in the amplification of platelet responses during thrombosis. Receptor activity is regulated by internalization and receptor desensitization. The mechanism by which constitutive surface expression of the TPαR is regulated is unknown.
View Article and Find Full Text PDF: The microbiological profile of bone and joint infections is important for determining the empiric choice of both systemic and local antimicrobial therapy. This study assessed whether there was a difference in the bacterial species that were isolated on culture in osteomyelitis (OM), fracture-related infection (FRI) or prosthetic joint infection (PJI). This was a retrospective, observational cohort study of patients who had surgical intervention for PJI or OM or FRI with a positive microbial culture between 2019 and 2022.
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- A study was conducted to compare the effectiveness of local antibiotic treatment using aminoglycoside alone versus a combination of aminoglycoside and vancomycin in patients undergoing surgery for bone infections.
- Out of 266 patients, 252 completed the study, showing similar therapy failure rates of 8.8% for aminoglycoside alone and 8.6% for the combination treatment, indicating no significant benefit to adding vancomycin.
- Factors like higher BACH scores and low body mass index (BMI) were associated with an increased risk of treatment failure, but the method of antibiotic delivery and the presence of aminoglycoside resistance did not affect outcomes.
Article Synopsis
- Megakaryocytes migrate to bone marrow sinusoids for platelet production, regulated by the CXCL12 chemokine and its CXCR4 receptor.
- Pim-1 kinase influences CXCR4 signaling, as inhibiting it reduces platelet aggregation and megakaryocyte migration in response to CXCL12.
- The reduction in CXCR4 signaling is due to decreased receptor levels on the surface of megakaryocytes and platelets, which has implications for treating conditions with high thrombotic risk related to elevated CXCL12.