Publications by authors named "A J Tsung"
Petroclival approaches remain challenging given abundant cranial nerves and vessels. Common trajectories include transsphenoidal, transoral, middle fossa-extradural, and posterior through the cerebellar peduncle. We report a unique intra-axial, intradural approach to the petroclival and cavernous sinus.
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- The study investigates how cancer cells influence the fitness of surrounding tumor microenvironment (TME) cells through a mechanism involving a long non-coding RNA called Tu-Stroma, which alters the expression of Flower isoforms, impacting their growth advantage.
- The expression of Flower Win isoforms in cancer cells enhances their dominance over TME cells that express Flower Lose isoforms, leading to reduced fitness in the TME.
- Targeting Flower proteins with a humanized monoclonal antibody in mice has shown promising results, significantly reducing cancer growth and metastasis while improving survival rates and protecting organs from potential lesions.
Article Synopsis
- Black patients with colon cancer show more aggressive tumors and treatment resistance compared to white patients, prompting a study on stage-specific genetic differences.
- Analysis of 247 patients revealed 312 genes differ in localized, 105 in regional, and 199 in distant stages, with the IL-17 pathway notably downregulated in localized disease for Black patients.
- Five genes consistently exhibited racial differences across all stages, indicating significant transcriptional disparities in colon cancer that could inform race-specific research and treatment approaches.