Publications by authors named "A J Trujillo"
Background: Measures to control COVID-19 transmission disrupted childhood cancer care. Data on the effects of the COVID-19 pandemic on childhood cancer mortality are lacking. This study describes the impact of the pandemic on childhood cancer early-mortality (≤ 24 months).
View Article and Find Full Text PDFObjective: This study investigated the effects of recombinant equine IL-31 (eIL-31) in vivo and in vitro.
Methods: Equine IL-31 mRNA sequences were verified by sequencing. Recombinant eIL-31 was produced using mammalian and bacterial expression systems.
The novel object recognition (NOR) test is an efficient way to measure nonspatial memory in rodents. The NOR performance of female and male rats is sexually dimorphic because memory performance is better in the former than in the latter. In females, maternal experience enhances spatial memory.
View Article and Find Full Text PDFDynamics of biological markets with multiple biosimilar competitors in the United States.
Expert Opin Biol Ther
November 2024
Article Synopsis
- The study investigates the competitive dynamics of biosimilars in the U.S. market, focusing on how many originator biologics have multiple competitors and how pricing evolves with their entry.
- Only five originator biologics had three or more biosimilar competitors by December 2022, with a mean lag of 9 months between approval and launch of these biosimilars.
- As more biosimilars entered the market, originator biologic prices decreased significantly, while their rebates increased, indicating a competitive response to biosimilar presence.
Article Synopsis
- The study investigates the dual motivations of pharmaceutical coupons, focusing on whether they primarily drive customer acquisition or retention.
- Using data from 1.1 million privately insured patients between 2017 and 2019, the research analyzes the impact of coupons on medication switching behavior and patient spending.
- Findings show that coupons reduce the likelihood of switching drugs by 1% overall and can lead to significant savings for patients, especially with anticoagulants, while the effect on switching behavior diminishes after the first coupon use.